Summary sheet on Commission
Review (ref. XXIV/1991/97)
Ingredient :
a-{4-[4-Dimethylamino-4'-(N-ethyl-3-sulfobenzylamino)-benzhydrylidene]-(N-ethyl-2,5-cyclohexylideneammonio)}3-tolylsulfonate
CAS n° : 1694-09-3
Function and max in use
concentration : previously used
as a colour classified food
additive
Relevant toxicity data :
Assessment of
carcinogenicity : carcinogenic
in rats following oral and
subcutaneous administration.
Increased incidence of benign
mammary tumours in female rats
following ambient exposure.
Assessment of
carcinogenicity : some evidence
of mutagenicity in Salmonella.
Human data : no data
available
Classification : 2a (See
Classification of Substances)
CI 42640 was previously
assessed by the SCC
(SCC/313/83)
Statement on the
toxicological evaluation
The SCCNFP is the
scientific advisory body to the
European Commission in matters
of consumer protection with
respect to cosmetics and
non-food products intended for
consumers.
The Commission's general
policy regarding research on
animals supports the
development of alternative
methods to replace or to reduce
animal testing when possible.
In this context, the SCCNFP has
a specific working group on
alternatives to animal testing
which, in co-operation with
other Commission services such
as ECVAM (European Centre for
Validation of Alternative
Methods), evaluates these
methods.
SCCNFP opinions include
evaluations of experiments
using laboratory animals; such
tests are conducted in
accordance with all legal
provisions and preferably under
chemical law regulations. Only
in cases where no alternative
method is available will such
tests be evaluated and the
resulting data accepted, in
order to meet the fundamental
requirements of the protection
of consumer health.