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Directorate-General for Health and Food Safety
Summary sheet on Commission
Review (ref. XXIV/1991/97)
Ingredient : Acetyl ethyl tetramethyl tetralin.
CAS n° : 88-29-9
Function and max in use concentration : fragrance ingredient, 1,2 % in perfumes.
Relevant toxicity data :
Assessment of chronic/sub-chronic toxicity : Very toxic for the CNS in repeated dose toxicity studies by dermal application (13 & 26 w.) Ý very low NOAEL.
Toxicokinetics:
- Wide distribution in lipid rich organs after i.p. or i.v. inj.
Classification: 2a (See Classification of Substances)
SCCNFP Opinion
After i.p. or i.v. injection, Acetyl ethyl tetramethyl tetralin (AETT) is widely distributed in lipid rich organs, mainly brain, spinal cord and nerve tracts and is extensively reabsorbed after redistribution via the liver.
In sub-chronic dermal studies, AETT treated animals exhibited clinical signs of neuro-toxicity confirmed by histological examination. Neuropathological changes occurred at very low doses and were dose and time dependant. NOAEL (rat skin application) = 3 mg/Kg/d.
The available data support the conclusion that AETT constitutes a hazard for the CNS after dermal exposure. The SCCNFP is of the opinion that AETT must not be used in cosmetic products.
Statement on the toxicological evaluation
The SCCNFP is the scientific advisory body to the European Commission in matters of consumer protection with respect to cosmetics and non-food products intended for consumers.
The Commission's general policy regarding research on animals supports the development of alternative methods to replace or to reduce animal testing when possible. In this context, the SCCNFP has a specific working group on alternatives to animal testing which, in co-operation with other Commission services such as ECVAM (European Centre for Validation of Alternative Methods), evaluates these methods.
SCCNFP opinions include evaluations of experiments using laboratory animals; such tests are conducted in accordance with all legal provisions and preferably under chemical law regulations. Only in cases where no alternative method is available will such tests be evaluated and the resulting data accepted, in order to meet the fundamental requirements of the protection of consumer health.
Ingredient : Acetyl ethyl tetramethyl tetralin.
CAS n° : 88-29-9
Function and max in use concentration : fragrance ingredient, 1,2 % in perfumes.
Relevant toxicity data :
Assessment of chronic/sub-chronic toxicity : Very toxic for the CNS in repeated dose toxicity studies by dermal application (13 & 26 w.) Ý very low NOAEL.
Toxicokinetics:
- Wide distribution in lipid rich organs after i.p. or i.v. inj.
Classification: 2a (See Classification of Substances)
SCCNFP Opinion
After i.p. or i.v. injection, Acetyl ethyl tetramethyl tetralin (AETT) is widely distributed in lipid rich organs, mainly brain, spinal cord and nerve tracts and is extensively reabsorbed after redistribution via the liver.
In sub-chronic dermal studies, AETT treated animals exhibited clinical signs of neuro-toxicity confirmed by histological examination. Neuropathological changes occurred at very low doses and were dose and time dependant. NOAEL (rat skin application) = 3 mg/Kg/d.
The available data support the conclusion that AETT constitutes a hazard for the CNS after dermal exposure. The SCCNFP is of the opinion that AETT must not be used in cosmetic products.
Statement on the toxicological evaluation
The SCCNFP is the scientific advisory body to the European Commission in matters of consumer protection with respect to cosmetics and non-food products intended for consumers.
The Commission's general policy regarding research on animals supports the development of alternative methods to replace or to reduce animal testing when possible. In this context, the SCCNFP has a specific working group on alternatives to animal testing which, in co-operation with other Commission services such as ECVAM (European Centre for Validation of Alternative Methods), evaluates these methods.
SCCNFP opinions include evaluations of experiments using laboratory animals; such tests are conducted in accordance with all legal provisions and preferably under chemical law regulations. Only in cases where no alternative method is available will such tests be evaluated and the resulting data accepted, in order to meet the fundamental requirements of the protection of consumer health.
