Summary sheet on Commission
Review (ref. XXIV/1431/96,
rev.: June 97)
Ingredient:
4,6-dinitro-1,1,3,3,5-pentamethylindane
(Musk Moskene)
CAS n° : 116-66-5
Function: Fragrance
ingredient
Max in use
concentration: not applicable
Assessment of acute
toxicity (dermal, oral, i.v.,
i.p.)
- oral: apparently low;
full report not available
- dermal: apparently
low; full report not available
Assessment of irritation
& corrosivity:
- low to mild irritation
in rabbits and humans
- not considered as an
eye irritant (OECD 405)
- not photo-irritant
Assessment of
chronic/sub-chronic toxicity:
- Repeated dose toxicity
(90d)
- dermal application:
within a reasonable NOAEL
- oral: no data
available
Assessment of
reproductive toxicity :
- no data available
Assessment of
genotoxicity/carcinogenicity:
- no evidence of
mutagenic potential in the
Salmonella test and chromosome
aberration assay
Assessment on
allergenicity/sensitisation:
- no sensitisation or no
photo-allergenicity
(pre-clinical)
Percutaneous absorption:
- In vitro: high
absorption rate (rat); lower to
moderate (pig)
Classification: 2a (see
Classification of Substances)
Statement on the
toxicological evaluation
The SCCNFP is the
scientific advisory body to the
European Commission in matters
of consumer protection with
respect to cosmetics and
non-food products intended for
consumers.
The Commission's general
policy regarding research on
animals supports the
development of alternative
methods to replace or to reduce
animal testing when possible.
In this context, the SCCNFP has
a specific working group on
alternatives to animal testing
which, in co-operation with
other Commission services such
as ECVAM (European Centre for
Validation of Alternative
Methods), evaluates these
methods.
SCCNFP opinions include
evaluations of experiments
using laboratory animals; such
tests are conducted in
accordance with all legal
provisions and preferably under
chemical law regulations. Only
in cases where no alternative
method is available will such
tests be evaluated and the
resulting data accepted, in
order to meet the fundamental
requirements of the protection
of consumer health.