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Directorate-General for Health and Food Safety
Summary sheet on Commission
Review (ref. XXIV/1468/97)
Ingredient: Strontium chloride hexahydrate
Function: technical advantages
Max in use concentration: 2.1 % calculated as elementary Strontium
Assessment of acute toxicity (dermal, oral, i.v., i.p.)
- oral toxicity low
- dermal toxicity low
Assessment of irritation & corrosivity:
- appropriate experiments with favourable results
Assessment of chronic/sub-chronic toxicity:
- Repeated dose toxicity (90d)
- oral: within a reasonable NOAEL
Assessment of genotoxicity/carcinogenicity:
- no mutagenicity in different tests
Assessment on allergenicity/sensitization:
- no sensitisation
Percutaneous absorption:
- in animal skin (in vivo) very low (89SrCl2)
- in human skin (in vitro) normal to low range (89SrCl2)
Classification: 1 (see Classification of Substances)
Statement on the toxicological evaluation
The SCCNFP is the scientific advisory body to the European Commission in matters of consumer protection with respect to cosmetics and non-food products intended for consumers.
The Commission's general policy regarding research on animals supports the development of alternative methods to replace or to reduce animal testing when possible. In this context, the SCCNFP has a specific working group on alternatives to animal testing which, in co-operation with other Commission services such as ECVAM (European Centre for Validation of Alternative Methods), evaluates these methods.
SCCNFP opinions include evaluations of experiments using laboratory animals; such tests are conducted in accordance with all legal provisions and preferably under chemical law regulations. Only in cases where no alternative method is available will such tests be evaluated and the resulting data accepted, in order to meet the fundamental requirements of the protection of consumer health.
Ingredient: Strontium chloride hexahydrate
Function: technical advantages
Max in use concentration: 2.1 % calculated as elementary Strontium
Assessment of acute toxicity (dermal, oral, i.v., i.p.)
- oral toxicity low
- dermal toxicity low
Assessment of irritation & corrosivity:
- appropriate experiments with favourable results
Assessment of chronic/sub-chronic toxicity:
- Repeated dose toxicity (90d)
- oral: within a reasonable NOAEL
Assessment of genotoxicity/carcinogenicity:
- no mutagenicity in different tests
Assessment on allergenicity/sensitization:
- no sensitisation
Percutaneous absorption:
- in animal skin (in vivo) very low (89SrCl2)
- in human skin (in vitro) normal to low range (89SrCl2)
Classification: 1 (see Classification of Substances)
Statement on the toxicological evaluation
The SCCNFP is the scientific advisory body to the European Commission in matters of consumer protection with respect to cosmetics and non-food products intended for consumers.
The Commission's general policy regarding research on animals supports the development of alternative methods to replace or to reduce animal testing when possible. In this context, the SCCNFP has a specific working group on alternatives to animal testing which, in co-operation with other Commission services such as ECVAM (European Centre for Validation of Alternative Methods), evaluates these methods.
SCCNFP opinions include evaluations of experiments using laboratory animals; such tests are conducted in accordance with all legal provisions and preferably under chemical law regulations. Only in cases where no alternative method is available will such tests be evaluated and the resulting data accepted, in order to meet the fundamental requirements of the protection of consumer health.
