Tumor instability and impact on patient survival: it all depends on the immune response
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Health Innovation Health, Demographic Change and Wellbeing Austria Czechia France Germany Netherlands Spaindate: 16/03/2016
Project: APERIM: Advanced bioinformatics platform...
acronym: APERIM
See also: CORDIS
Genetic and molecular characteristics are often used to classify tumors because stratification is the first step towards individualized cancer medicine with the aim to find the optimal treatment for each patient. In colorectal cancer for an example the diagnosis to have a genetic instable tumor indicates a favorable prognosis for the patient. Researchers from the Laboratory of Integrative Cancer Immunology led by Jérôme Galon (Inserm, Universités Pierre-et-Marie-Curie et Paris Descartes, Cordeliers Research Center in Paris, France) now could prove that the immunologic environment in and around colorectal cancer even plays a greater role to stratify tumors than classification based on tumor (in)stability. These results could have important clinical implications for immunotherapy.