Magnetic nanoparticles (MNPs) have generated great interest in the field of cancer nanotheranostics owing to their intrinsic magnetic property that enables them to be used as contrast agents in magnetic resonance imaging and as a therapeutic system. In addition, the magneto-mechanical actuation of MNPs by alternating magnetic fields and its possible use for remote control of nanomedicines and drug delivery systems, in conjunction with magnetic hyperthermia, opens very interesting prospects for the nanomedicines of the future. For all those reasons, I strongly support the proposed topics.

These subjects are showing a huge progress and going-on working is key to get the expected impact in health and ambient.

Very promising line. Considering "artificial organs" I would introduce the topic of magnetically driven 3D bio-printing

The proposal have an actual and interesting topics. Its important to point out that nanotechnoly, based on nanoparticles (shells, rods etc.) could be used for cancer treatment. Moreover nanoscale materials (carbon nanotubes, nanocomposites, nanoparticles), possess exceptional physic-mechanical, electronic, magnetic, electrical, chemical, optical and so on properties. They find applications in transistors, semiconductors, electronics, medicine.
I support warmly the proposal!

I strongly support the proposed topics.

I strongly support the proposed topics.

Hi All in the forum,
UK has very strong reseach groups as well as SEM in this area. So, wholehearted, I support research and enterprise activities on magnetic nanoparticles.
You can see the domination of European groups in this book:
"MAGNETIC NANOPARTICLES: FROM FABRICATION
TO CLINICAL APPLICATIONS" CRC Press/Taylor and Francis:
http://www.crcpress.com/product/isbn/9781439869321
Kind regards
Thanh

This is key research topic and i fully support it.

I like this idea.
I would suggest, as a further development of it, intrinsic magnetisation of mammalian cells as delivery vehicles for theranosntic applications.

Magnetic nanohybrids (MNHs) provide a unique toolbox for theranostics applications, since they can be remotely and non-invasively employed as smart actuators and carrier vectors. Among, their major advantages are the tunable magnetic features, the bio-compatibility, the diversity of functionalization and the appropriate size scale comparable to functional biomolecules.
Beside the magnetic core which is actually the driving force for magnetic hyperthermia, these nanoplatforms may be functionalized with extra action(s) triggered only during magnetic field exposure. Such triggers can be a highly effective new nanoscale tool useful for a variety of systems that rely on heat induction, initiating from magnetic hyperthermia therapy but go beyond current modalities with add-on tools such as on-demand drug release and thermal activation of metabolic pathways within a single cell.
Eventually, hyperthermia-based treatments combined with drug delivery approaches based on magnetic nanomaterials will move pharmaceutical industry from current blockbuster drug models to personalized medicine schemes.
Ultimately, a future is envisioned in which nanostructured materials are created with multifunctionalities with optimized pharmacokinetics and pharmacodynamics offering most effective and truly intelligent therapies adequately combined with real time diagnostic modalities to create a truly intelligent theranostics.

It is one of the most important scientific topics addressing social needs.
I strongly support it.

Excellent idea for UE development!!!

Functionalized nanoparticle fabrication and detection will be perhaps the most sensitive way for cells, viruses and protein detection.

The development of multifunctional nanosize materials will play a key role in the development of the future treatment protocols and diagnostics, as for the in-vivo molecular imaging of metabolic processes for example. I strongly support this proposal.

Understanding the static and dynamic magnetic properties of functionalized nanoparticles is essential for the development and optimization of the applications explained above and to find even more applications in the future. The wide range of possible uses for the nanoparticles makes this topic very important!

I think it's an excellent idea and I fully support it

Thank you for proposing this Michael - it is very timely and much needed if we in Europe are to capitalise on our expertise in the field, and convert it into real translational success stories. We are already doing well - we have the world's highest concentration of magnetic nanoparticle based SMEs, ranging from Dynal and Miltenyi right down to my own spinout, Endomagnetics (which sells the world's first non-pharmaceutical clinically-approved magnetic particle) - but if we are to make the most of this, a concerted action is needed, now. Best wishes, Quentin.

Europe must continue to be at the fore-front of science in the clinical applications of magnetic NPs: as you can check-out in the program of http://magneticmicrosphere.com/meeting-eleventh, many European researchers are world-class leaders in this area!
For instance depending on their sizes, iron oxide NPs can be both positive (T1) and negative (T2) contrast agents and may replace paramagnetic contrast agent on the market (Gd3+ chelates exhibit drawbacks and could be advantageously replaced by individually dispersed ultra-small iron oxide NPs with efficient organic stealth shells).
Magnetic hyperthermia combined with chemo-toxic drugs (magneto-chemotherapy) could also enable fighting against incurable diseases such as glioblastoma... for all those reasons, research on the design and large-scale production of magnetic NP-based nanomedecine must be supported by EU calls for the benefit of all the European population!

Multifunctionality could be the key. It would have been interesting to highlight the major challenges.

Excellent idea, magnetic nanoparticles have had a great success in recent years and merit a call

This is a truely great approach - good luck!

Excellent