This study was realised for an Interact expert assignment by “EureConsult”(Luxembourg,  Lead  Partner),“t33”(Italy) and “Spatial Foresight”(Luxembourg). It gives a long-term analysis on european labour market integration through cross-border and transnational integration, through both a general analysis and case study analyses (cross-border areas such as the Greater Region and Italy-Slovenia; and transnational cooperation areas such as the Baltic sea Region or the Alpine Space).