This Report is aimed at illustrating the points of contact and synergies between Global Value Chains (GVCs), Foreign Direct Investment (FDI) and national and regional development trajectories. The Report provides key facts and figures and a tentative analytical and policy framework to detect opportunities and challenges confronted by the Member States of the European Union (EU) and their regions. The growing interdependence of national and regional economies in the international division of labour in GVCs and FDI shapes design, implementation and evaluation of public policies for internationalisation, innovation and economic development at the regional, national and EU level.