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TOPIC : Assessing the health risks of combined human exposure to multiple food-related toxic substances

Topic identifier: SFS-12-2014
Publication date: 11 December 2013

Types of action: RIA Research and Innovation action
DeadlineModel:
Opening date:
two-stage
11 December 2013
Deadline:
2nd stage Deadline:
12 March 2014 17:00:00
26 June 2014 17:00:00

Time Zone : (Brussels time)
  Horizon 2020
Topic Description
Scope:

Specific challenge: Risk assessment has long been the tool for science-based decision-making and has become an integral part of EU policy development. With regard to chemical hazards, there is increasing concern over the possible ‘cocktail effects’ of combined exposure to multiple food related toxic substances. The complex toxicology of chemical mixtures, and the diversity of the routes of exposure, call for the development of a more mechanism-based and quantitative framework for risk assessment estimating the impact on health, thereby increasing the efficiency and effectiveness of safety evaluations.

Scope: The state-of-the-art frameworks already in place at international level should be reviewed in the quest for a harmonised, evidence- and risk-based approach. Proposals should focus on the health risks of combined exposures to multiple chemicals from multiple sources across differing life stages, while weighing the risks from chemical mixtures in diets against the health benefits from the same foods and taking into account also the gender dimension. New strategies should be developed, implemented and supported by the respectively developed software and databases and tested in operational environments – using, for example, ‘omics’ technologies, bioassay systems, mathematical modelling, quantitative structure-activity relationship models and threshold of toxicological concern – so that tiered approaches for testing can be followed and targeted testing protocols developed. Proposals should address responsible research and innovation aspects by developing strategies that will result in a reduction in the use of animals in toxicological research.

The Commission considers that proposals requesting a contribution from the EU in the range of EUR 8 million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts.

Expected impact:

         New strategies that help boost innovation in both the public and private sectors and  significantly improve the robustness and efficiency of risk assessment

         Improvement in public health through a reduction in food-related toxic substances

         Free access for public authorities to the new software and databases developed beyond the lifetime of the projects

         A reduction in the use of animals in toxicological research

         Support to EU, Codex Alimentarius, and WHO health and food safety policies through the development of new risk assessment strategies 

Type of action: Research and innovation actions

Topic conditions and documents

Please read carefully all provisions below before the preparation of your application.

  1. List of countries and applicable rules for funding: described in part A of the General Annexes of the General Work Programme.
     
  2. Eligibility and admissibility conditions: described in part B and C of the General Annexes of the General Work Programme. 
     
  3. Evaluation

    3.1  Evaluation criteria and procedure, scoring and threshold: described in part H of the General Annexes of the General Work Programme. 

    3.2 Guide to the submission and evaluation process



     
  4. Proposal page limits and layout: Please refer to Part B of the standard proposal template.
     
  5. Indicative timetable for evaluation and grant agreement:
    Information on the outcome of one-stage evaluation: maximum 5 months from the final date for submission.
    Signature of grant agreements: maximum 3 months from the date of informing successful applicants.

    Information on the outcome of two-stage evaluation: maximum 5 months from the final date for submission.
    Signature of grant agreements: maximum 3 months from the date of informing successful applicants.
     

     
  6. Provisions, proposal templates and evaluation forms for the type(s) of action(s) under this topic:

    Research and Innovation Action:

    Specific provisions and funding rates
    Standard proposal template (administrative forms and structure of technical annex)
    Standard evaluation form
    Annotated Model Grant Agreement



     
  7. Additional provisions:

    Horizon 2020 budget flexibility

    Classified information

    Technology readiness levels (TRL) – where a topic description refers to TRL, these definitions apply.

    Financial support to Third Parties – where a topic description foresees financial support to Third Parties, these provisions apply.

     
  8. Open access must be granted to all scientific publications resulting from Horizon 2020 actions, and proposals must refer to measures envisaged. Where relevant, proposals should also provide information on how the participants will manage the research data generated and/or collected during the project, such as details on what types of data the project will generate, whether and how this data will be exploited or made accessible for verification and re-use, and how it will be curated and preserved.

 

Additional documents

  • Legal basis - Framework Programme H2020 en
  • Legal basis - Specific Programme H2020 en
  • WP H2020 - 1. Introduction en
  • WP H2020 - 9. Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy en
  • WP H2020 - 17. Communication and Dissemination en
  • WP H2020 - 19. General Annexes en
  • Call update - Results of the re-evaluation of proposals submitted under SFS-14a topic en
  • Flash info en

Submission Service

No submission system is open for this topic.

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H2020 Online Manual your online guide on the procedures from proposal submission to managing your grant.