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TOPIC : Multi omics for personalised therapies addressing diseases of the immune system

Topic identifier: SC1-PM-01-2016
Publication date: 14 October 2015

Types of action: RIA Research and Innovation action
DeadlineModel:
Opening date:
single-stage
20 October 2015
Deadline: 13 April 2016 17:00:00

Time Zone : (Brussels time)
  Horizon 2020 H2020 website
Pillar: Societal Challenges
Work Programme Year: H2020-2016-2017
Topic Description
Specific Challenge:

Despite much progress in 'omics' and epidemiological research in recent years, the knowledge on the combined role of genetic and non-genetic factors in health and disease is still limited, thus hampering the full development potential of personalised medicine[1].

There is increasing evidence that interactions with the environment, as reflected in genome-epigenome-proteome-metabolome-microbiome crosstalk, play an important role in disease development and progression. International initiatives such as the International Cancer Genome Consortium (ICGC), the International Human Epigenome Consortium (IHEC) and the International Human Microbiome Consortium have generated high quality comprehensive large scale data catalogues and maps. The challenge is to build on the existing high quality data deposited in relevant databases (e.g. but not limited to: http://epigenomesportal.ca/ihec/, http://docs.icgc.org/data-portal) and combine these data and knowledge with lifestyle and environmental data, thus accelerating the translation into novel targeted or personalized interventions. These objectives cannot be accomplished on an individual country level which calls for broad transnational collaboration.

Scope:

The scope of this topic is to integrate and use high quality genome, epigenome, proteome, metabolome, microbiome data produced by large scale international initiatives with innovative imaging, functional, structural and lifestyle/environmental data, and combine these with disease-oriented functional analysis to contribute to the understanding of health and disease with the final objective of selecting relevant biomarkers for clinical validation that will lead to the development of new targeted therapies for diseases of the immune system. Proposals must build on data from IHEC and, as appropriate, on data from other international initiatives. Proposals should address relevant ethical implications, take into account sex and gender differences and include a section on research data management. International cooperation is requested. Proposals addressing rare diseases of the immune system are not in scope of this action.

The Commission considers that proposals requesting a contribution from the EU of between EUR 12 and 15 million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts.

Expected Impact:
  • Translate big data and basic research results into clinical applications.
  • Contribute to exploiting data from IHEC and, as appropriate, data from other international initiatives.
  • Identify and select new biomarkers for clinical validation in stratified patient populations
  • Develop new targeted therapies for diseases of the immune system with high prevalence.
  • In line with the Union's strategy for international cooperation in research and innovation proposals should create strategic synergies between scientists across disciplines, sectors and around the globe.
Cross-cutting Priorities:

Gender
International cooperation

[1]Personalised medicine refers to a medical model using characterization of individuals’ phenotypes and genotypes (e.g. molecular profiling, medical imaging, lifestyle data) for tailoring the right therapeutic strategy for the right person at the right time, and/or to determine the predisposition to disease and/or to deliver timely and targeted prevention. The term "personalised medicine" is used throughout this Work Programme with this definition in mind.

Topic conditions and documents

Please read carefully all provisions below before the preparation of your application.
 

  1. List of countries and applicable rules for funding: described in part A of the General Annexes of the General Work Programme.
    Note also that a number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon 2020 projects (follow the links to China, Japan, Republic of Korea, Mexico, Russia, Taiwan, USA).

     
  2. Eligibility and admissibility conditions: described in part B and C of the General Annexes of the General Work Programme.

    Proposal page limits and layout: Please refer to Part B of the standard proposal template.

     
  3. Evaluation

    3.1  Evaluation criteria and procedure, scoring and threshold: described in part H of the General Annexes of the General Work Programme, with the following exceptions: The thresholds for each criterion in a single stage process will be 4, 4 and 3. The cumulative threshold will be 12.

    3.2 Submission and evaluation process: Guide to the submission and evaluation process

          
  4. Indicative timetable for evaluation and grant agreement:

    Information on the outcome of single-stage evaluation: maximum 5 months from the deadline for submission.
    Signature of grant agreements: maximum 8 months from the deadline for submission.

     
  5. Provisions, proposal templates and evaluation forms for the type(s) of action(s) under this topic:

    Research and Innovation Action:

    Specific provisions and funding rates
    Standard proposal template
    Specific evaluation form
    H2020 General MGA -Multi-Beneficiary
    Annotated Grant Agreement

     
  6. Additional provisions:

    Horizon 2020 budget flexibility

    Classified information

     
  7. Open access must be granted to all scientific publications resulting from Horizon 2020 actions, and proposals must refer to measures envisaged. Where relevant, proposals should also provide information on how the participants will manage the research data generated and/or collected during the project, such as details on what types of data the project will generate, whether and how this data will be exploited or made accessible for verification and re-use, and how it will be curated and preserved.

     
  8. Additional documents:

    H2020 Work Programme 2016-17: Health, demographic change and wellbeing

    H2020 Work Programme 2016-17: Dissemination, Exploitation and Evaluation

    H2020 Work Programme 2016-17: General Annexes

    Legal basis: Horizon 2020 - Regulation of Establishment

    Legal basis: Horizon 2020 Rules for Participation

    Legal basis: Horizon 2020 Specific Programme

 

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