Research & Innovation - Participant Portal


TOPIC : Support and coordination action for the projects of the Neurodegeneration area of the Innovative Medicines Initiative

Topic identifier: IMI2-2017-13-05
Publication date: 30 November 2017

Types of action: IMI2-CSA Coordination & support action
Opening date:
30 November 2017
2nd stage Deadline:
28 February 2018 17:00:00
06 September 2018 17:00:00

Time Zone : (Brussels time)
  Horizon 2020
Topic Description
Specific Challenge:

Effective and efficient collaboration and coordination among the IMI portfolio of projects in the area of Neurodegeneration and related national, European and global initiatives is a key success factor for the important public-private investment to achieve its full impact, as also highlighted in a recent meeting hosted in Brussels by the IMI2 JU.

It also is evident that projects share several areas of common interest (e.g. modelling and simulation, imaging) and have developed best practices that would be very useful for other ongoing and upcoming initiatives, but due to the silo-like structure of the individual initiatives, the opportunity for real and effective cross fertilisation is limited and based on the “good will” of enthusiastic individuals. The portfolio of IMI projects has grown significantly and it is diverse in scope and focus, making the need for a more structural and tailor-made support structure mandatory.

Projects would also benefit from support (including access to learnings from other projects) towards the submission of results for regulatory and/or health-technology assessment (HTA) to ensure that important results can timely impact regulatory practice and the health care system. Often the data to support a regulatory/HTA submission are only fully available in the very final phase of the projects or even after their official end which may hamper their submission and subsequent follow up.

A significant challenge in collaboration is the burden required to develop agreements and good practices for sharing and re-use of data, biological tools (e.g. cell lines) and other materials, activities that are normally either not or only minimally resourced under individual initiatives and can be labour intensive and require expertise (e.g. legal, ethical) not always readily available for each project.

All projects face the challenge of sustainability of their results, and the lack of a source of advice and support in finding/choosing relevant solutions beyond the project lifetime.

There is therefore a clear need for support to ensure that collaboration and coordination become intentional and structural to the portfolio of projects in the IMI strategic area of neurodegeneration, by providing the necessary resources and framework.

Last but not least there would be a very high value in having a framework to facilitate collaboration and coordination of the many initiatives focussed on neurodegeneration, in and beyond IMI, and to develop some metrics to show their value in advancing research and remove bottlenecks toward the delivery of innovative treatments to patients.


The overall scope of the coordination and support action is to provide the necessary overall framework and resources to achieve effective and efficient coordination and collaboration among the ongoing and future projects in the IMI strategic area of neurodegeneration. This will include:

  • Develop a framework to coordinate and support the operational alignment of the IMI Neurodegeneration research portfolio, including a process to ensure that projects make appropriate use and can access existing infrastructures;
  • Provide expert advice and other support to facilitate sharing and access of data, biological tools and other materials among projects;
  • Provide expert advice and support in preparing for regulatory and/or HTAs interactions (e.g. legal support, access to relevant expertise, funding to pay submission fees) to ensure that appropriate regulatory input is provided when most valuable and also beyond the timeframe of a project;
  • Establish and manage workshops designed to share common approaches/best practice across IMI projects and beyond;
  • Develop a framework to coordinate and efficiently support the operational alignment of the IMI led actions with other relevant partnerships and initiatives at national, European and global level
  • Create a platform to enable the mapping of partnerships and collaborative efforts that have supported over the past years research in Alzheimer’s disease to capture their contributions and identify the remaining gaps and develop metrics and benchmarks to measure value, including socio-economic impact;
  • Develop outreach and engagement actions with other international/national/regional initiatives including patient organizations to promote and increase the value of trans-national and international research collaborations;
  • Communicate and disseminate on joint activities and initiatives in the field of neurodegenerative diseases;
  • Seek alignment and coordination on issues of common interest such as Ethical, Legal and Social Implications of clinical neurodegenerative disease (especially Alzheimer’s disease) research, where several learnings are already available but disperse.
Expected Impact:

The expected impact would be:

  • An enhanced impact of the individual projects by creating structural synergy and collaboration;
  • An enhanced visibility of the significant public and private investment of IMI in the area of Neurodegeneration; To ensure the results of IMI projects are developed optimally for the benefit of patients and the health systems including strategies for sustainability and uptake;
  • An optimization of the impact of IMI projects’ activities in neurodegeneration toward the achievement of the IMI2 Council Regulation objectives
  • An analysis of the scientific results and achievements delivered by the various partnerships in neurodegeneration so far, and an understanding of their translation into more efficient and faster development of new medical products in this area and of critical factors for a successful translation;
  • An overview and a framework to inform future collaborative research globally and facilitate the translation to innovative treatments for patients.

SMEs can be of great benefit to IMI projects and, inter-alia strengthen the competitiveness and industrial leadership of Europe. Their involvement might offer a complementary perspective to industry and the academia, and help deliver the long-term impact of the project. For these reasons, applicants should consider engaging SMEs throughout the proposal.

Topic conditions and documents

Please read carefully all provisions below before the preparation of your application.

The IMI2 13th Call for proposals topic text as well as the Call Conditions are available here.

 The budget breakdown for this Call is given at the end of the Call topics text, in the Call Condtions section, as well as the following information:

1.   Eligible countries: described in article 10(2) of the Rules for participation in Horizon 2020 and in article 1 of the Commission Delegated Regulation related to IMI JU.

2.   Eligibility and admissibility conditions: described in the IMI2 Manual for evaluation, submission and grant award. See also the Commission Delegated Regulation related to IMI JU.

Proposal page limits and layout: Please refer to Part B of the proposal template in the submission tool below.

3.   Evaluation:
Submission and evaluation process, including evaluation criteria and procedure, scoring and threshold are described in the IMI2 Manual for submission, evaluation and grant award. See also the proposal templates for your specific action in section 5, below.

4.   Indicative time for evaluation and grant agreement:
Notification of outcomes of stage 1 evaluations: maximum 5 months from deadline for submitting proposals.
Notification of outcomes of stage 2 evaluations: maximum 5 months from deadline for submitting full proposals.

Signature of grant agreements: maximum 3 months from the date of informing successful applicants.

5.   Proposal templates, evaluation forms and model grant agreements (MGA), clinical trials template:

IMI2 Research and Innovation Action (IMI2-RIA) and Innovation Action (IMI2-IA):

Proposal templates are available after entering the submission tool.

Standard evaluation form RIA 

IMI2 Model Grant Agreement
Members of consortium are required to conclude a consortium agreement prior to the signature of the grant agreement.

Clinical trial template:
The Clinical Trial template is compulsory at stage 2 only !

IMI2 Coordination and Support Action (IMI2-CSA):

Proposal templates are available after entering the submission tool.

Standard evaluation form CSA

IMI2 Model Grant Agreement
Members of consortium are required to conclude a consortium agreement prior to the signature of the grant agreement.

Clinical trial template:
The Clinical Trial template is compulsory at stage 2 only !

6.   Open access must be granted to all scientific publications resulting from Horizon 2020 actions.

Where relevant, proposals should also provide information on how the participants will manage the research data generated and/or collected during the project, such as details on what types of data the project will generate, whether and how this data will be exploited or made accessible for verification and re-use, and how it will be curated and preserved.

Open access to research data
The Open Research Data Pilot has been extended to cover all Horizon 2020 topics for which the submission is opened on 26 July 2016 or later. Projects funded under this topic will therefore by default provide open access to the research data they generate, except if they decide to opt-out under the conditions described in Annex L of the H2020 main Work Programme. Projects can opt-out at any stage, that is both before and after the grant signature.

Note that the evaluation phase proposals will not be evaluated more favourably because they plan to open or share their data, and will not be penalised for opting out.

Open research data sharing applies to the data needed to validate the results presented in scientific publications. Additionally, projects can choose to make other data available open access and need to describe their approach in a Data Management Plan.

Projects need to create a Data Management Plan (DMP), except if they opt-out of making their research data open access. A first version of the DMP must be provided as an early deliverable within six months of the project and should be updated during the project as appropriate. The Commission already provides guidance documents, including a template for DMPs. See the Online Manual.

Eligibility of costs: costs related to data management and data sharing are eligible for reimbursement during the project duration.

The legal requirements for projects participating in this pilot are in the article 29.3 of the Model Grant Agreement.

7. Additional documents:

Summary of the most relevant provisions for participating in IMI2 actions

IMI2 - 2nd Amendment to the Annual Work Plan 2017

IMI2 Regulators Guidance tool for researchers

IMI JU derogation to H2020 Rules for Participation  

Horizon 2020 Rules for Participation 

Horizon 2020 Regulation of Establishment

Horizon 2020 Specific Programme


Members of consortium are required to conclude a consortium agreement prior to the signature of the grant agreement.

Additional documents

  • IMI2 Call 13 stage 1 - Flash Call Info Report en
  • IMI2 Call 13 stage 2 - Flash Call Info Report en

Submission Service

No submission system is open for this topic.

Get support

H2020 Online Manual is your guide on the procedures from proposal submission to managing your grant.

Participant Portal FAQ – Submission of proposals.

National Contact Points (NCP) - contact your NCP for further assistance in your national language(s).

Research Enquiry Service – ask questions about any aspect of European research in general and the EU Research Framework Programmes in particular.

Enterprise Europe Network – contact your EEN national contact for advice to businesses with special focus on SMEs. The support includes guidance on the EU research funding.

IT Helpdesk - contact the Participant Portal IT helpdesk for questions such as forgotten passwords, access rights and roles, technical aspects of submission of proposals, etc.

IMI2 States Representative Group (SRG) – contact you SRG member for assistance.

IMI2 JU Applicants Helpdesk  – contact the IMI2 Programme Office.

IMI2 Partner Search Tool
 helps you find a partner organisation for your proposal

Ethics – for compliance with ethical issues, see the Online Manual and Science and Society Portal

European IPR Helpdesk assists you on intellectual property issues

CEN and CENELEC, the European Standards Organisations, advise you how to tackle standardisation in your project proposal. Contact CEN-CENELEC Research Helpdesk at

The European Charter for Researchers and the Code of Conduct for their recruitment