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TOPIC : Microbial chassis platforms with optimized metabolic pathways for industrial innovations through systems biology

Topic identifier: BIOTEC-03-2016
Publication date: 14 October 2015

Types of action: RIA Research and Innovation action
DeadlineModel:
Opening date:
two-stage
15 October 2015
Deadline:
2nd stage Deadline:
08 December 2015 17:00:00
24 May 2016 17:00:00

Time Zone : (Brussels time)
  Horizon 2020 H2020 website
Pillar: Industrial Leadership
Work Programme Year: H2020-2016-2017
Topic Description
Specific Challenge:

Systems biology deals with the understanding and controlling the complexity of living beings as opposed to studying their constituent parts. As such, systems biology can be considered as a cross-discipline, i.e. the integration of varied types of biological information and the development of models and networks, which together provide greater understanding of the biological system under study. Systems biology relies on cutting-edge technologies, including those in the fields of "omics" (genomics, transcriptomics, proteomics, metabolomics) and bioinformatics, all offering massive amounts of data, most of which remain stored and underexploited. Therefore, it is a growing area of science that builds information from the translation of biological data and strives to transfer knowledge to society in the form of valuable products and processes.

On the other hand, microbes are attractive candidates to serve as cell factories for the production of many valuable compounds useful for the food, feed, fuel, cosmetics and pharmaceutical industries. The current availability of genome sequences and metabolic models offers the adequate resources for the full exploitation of systems biology in industrial biotechnology, which can boost the design of novel and more efficient microbial platforms for the production of industrial compounds through the sound knowledge of their molecular constituents.

Scope:

Proposals should use systems biology approaches integrating "omics" data analysis, mathematical modelling and knowledge of interactions between cellular components under different environmental conditions, to enable useful applications for a broader set of microorganisms, while also achieving some of the following:

  • More efficient metabolic pathways of current microbial platforms, adapting them to high performing manufacturing processes
  • Improving existing cell factories or developing new ones with enhanced properties for harsh process conditions in industrial applications
  • Development of efficient cell factories for the industrial production of novel high-value products.
  • Identification of new microbial strains with beneficial characteristics for industrial applications such as those originating from extremophiles and related activities to develop relevant industrial host organisms.

Activities are expected to focus on Technology Readiness Levels 3 to 5. This topic addresses cross-KET activities.

The participation of SMEs is encouraged.

The Commission considers that proposals requesting a contribution from the EU between EUR 5 and 7 million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts.

Expected Impact:
  • Development of at least two new high added-value products
  • Boosting technological innovation for European industries to keep the leadership in biotechnology in particular in the food, feed, fuel, cosmetics and pharmaceutical industries.
  • An offer of substantial opportunities for an increasing number of SME to uptake innovative research.
  • Development of widely exploitable microbial hosts for the production of industrial goods.

Proposals should include a business case and exploitation strategy, as outlined in the Introduction to the LEIT part of this Work Programme.

Cross-cutting Priorities:

Cross-cutting Key-Enabling Technologies (KETs)

Topic conditions and documents

Please read carefully all provisions below before the preparation of your application.
 

  1. LIST OF COUNTRIES and APPLICABLE RULES FOR FUNDING
    described in part A of the General Annexes of the General Work Programme.

    Note also that a number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon 2020 projects (follow the links to Australia, Brazil, Canada, China, Hong Kong &Macau, India, Japan, Republic of Korea, Mexico, Russia, Taiwan).
     
  2. ELIGIBILITY and ADMISSIBILITY CONDITIONS
    described in part B and C of the General Annexes of the General Work Programme.

    Proposal page limits and layout: Please refer to Part B of the standard proposal template.


     
  3. EVALUATION

    3.1  Evaluation criteria and procedure, scoring and threshold: described in part H of the General Annexes of the General Work Programme , with the following exceptions:

    For single-stage and second-stage evaluations, the threshold for the criteria Excellence and Impact will be 4.
    The overall threshold, applying to the sum of the three individual scores, will be 12.

    In case of equal overall scores in the ranked list, the priority order of proposals will be established in accordance with part H of the General Annexes, except that proposals will be ranked on the basis of individual scores for the Impact criterion before the Excellence criterion.

    In case of equal overall scores in the ranked list, the priority order of proposals will be established in accordance with part H of the General Annexes, except, when comparing ex aequo proposals of different topics, the proposals will be ranked first according to the position in the topic ranked lists

    3.2 Submission and evaluation process: Guide to the submission and evaluation process
        
  4. INDICATIVE TIMETABLE for EVALUATION and GRANT AGREEMENT

    Information on the outcome of two-stage evaluation:
          For stage 1: maximum 3 months from the deadline for submission.
          For stage 2: maximum 5 months from the deadline for submission.
    Signature of grant agreements: maximum 8 months from the deadline for submission.

     
  5. PROVISIONS, PROPOSAL TEMPLATES and EVALUATION FORMS
    for the type of action under this topic


    Research and Innovation Action:

    Specific provisions and funding rates
    Standard proposal template
    Standard evaluation form
    H2020 General MGA -Multi-Beneficiary
    Annotated Grant Agreement
     
  6. ADDITIONAL PROVISIONS

    Horizon 2020 budget flexibility

    Classified information

    Technology readiness levels (TRL) – where a topic description refers to TRL, these definitions apply.

    Financial support to Third Parties – where a topic description foresees financial support to Third Parties, these provisions apply.

     
  7. OPEN ACCESS
    must be granted to all scientific publications resulting from Horizon 2020 actions, and proposals must refer to measures envisaged. 


    Where relevant, proposals should also provide information on how the participants will manage the research data generated and/or collected during the project, such as details on what types of data the project will generate, whether and how this data will be exploited or made accessible for verification and re-use, and how it will be curated and preserved.
     
  8. ADDITIONAL DOCUMENTS

    Legal basis: Horizon 2020 - Regulation of Establishment

    Legal basis: Horizon 2020 Rules for Participation

    Legal basis: Horizon 2020 Specific Programme

    H2020 Work Programme 2016-17: Introduction

    H2020 Work Programme 2016-17: Introduction to Leadership in enabling and industrial technologies (LEITs)

    H2020 Work Programme 2016-17: Nanotechnologies, advanced materials, advanced manufacturing and processing, biotechnology

    H2020 Work Programme 2016-17: Cross-cutting activities (Focus Areas)

    H2020 Work Programme 2016-17: Dissemination, Exploitation and Evaluation


    H2020 Work Programme 2016-17: General Annexes

 

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