Navigation path

Countries
Countries
  Algeria
  Argentina
  Australia
  Austria
  Bangladesh
  Belarus
  Belgium
  Benin
  Bolivia
  Botswana
  Brazil
  Bulgaria
  Burkina Faso
  Cambodia
  Cameroon
  Canada
  Cape Verde
  Chile
  China
  Colombia
  Costa Rica
  Croatia
  Cyprus
  Czech Republic
  Denmark
  Ecuador
  Egypt
  Estonia
  Ethiopia
  Faroe Islands
  Finland
  France
  Gambia
  Georgia

Countries
Countries
  Algeria
  Argentina
  Australia
  Austria
  Bangladesh
  Belarus
  Belgium
  Benin
  Bolivia
  Botswana
  Brazil
  Bulgaria
  Burkina Faso
  Cambodia
  Cameroon
  Canada
  Cape Verde
  Chile
  China
  Colombia
  Costa Rica
  Croatia
  Cyprus
  Czech Republic
  Denmark
  Ecuador
  Egypt
  Estonia
  Ethiopia
  Faroe Islands
  Finland
  France
  Gambia
  Georgia


  

Published: 6 January 2017  
Related theme(s) and subtheme(s)
Health & life sciences
Research policyHorizon 2020
Special CollectionsCancer
Countries involved in the project described in the article
Belgium  |  Italy  |  Netherlands  |  Spain
Add to PDF "basket"

Targeted treatments for advanced-stage bowel cancer

The EU-funded MoTriColor project is seeking to develop novel therapies for advanced-stage bowel cancer patients by targeting treatments according to each patient's disease subtype.

Picture of the men on medical examination

© Tyler Olson - fotolia.com

It is estimated that colorectal cancer (CRC), also known as bowel cancer, is currently third in the list of incurable cancers in terms of lives lost. Because early detection is difficult, sufferers often go undiagnosed until the cancer is at an advanced stage, leading to particularly poor prognosis.

During a previous EU-funded project – COLTHERES – MoTriColor investigators identified several distinct subgroups of CRC. Based on these findings, the MoTriColor project is developing tailored therapeutic options for CRC using molecular tests developed by the SME Agendia. The objective is to improve both prognosis and treatment outcome for patients suffering from metastatic CRC who have not responded to standard therapies.

It is estimated that up to 30 % of these unresponsive patients present one of the disease profiles MoTriColor is addressing.

The project consortium has identified three different CRC subtypes using molecular classification. Patients will be divided into three corresponding groups for Phase II clinical trials, which will explore the safety, tolerability and efficacy of the medication for each subtype. MoTriColor will also analyse any resistance to the treatments and validate the Coloprint® test developed by Agendia.

This will help medical experts identify which CRC patients may be susceptible to secondary resistance to the therapies, saving precious time in selecting treatment options during the advanced stages of the disease.

The MoTriColor project aims to set precedence for novel therapies in the wider field of chronic, non-communicable diseases by introducing the use of molecular diagnostic testing for better prognosis and treatment options. If the expected results are achieved, the project outcomes alone could benefit up to 30 000 CRC suffers in the EU today, not to mention those diagnosed in the future.

Project details

  • Project acronym: MoTriColor
  • Participants: Spain (Coordinator), Netherlands, Belgium, Italy
  • Project N°: 635342
  • Total costs: € 5 996 992
  • EU contribution: € 5 996 992
  • Duration: October 2015 – September 2019

See also

 

Convert article(s) to PDF

No article selected


loading


Search articles

Notes:
To restrict search results to articles in the Information Centre, i.e. this site, use this search box rather than the one at the top of the page.

After searching, you can expand the results to include the whole Research and Innovation web site, or another section of it, or all Europa, afterwards without searching again.

Please note that new content may take a few days to be indexed by the search engine and therefore to appear in the results.

Print Version
Share this article
See also
Project website
Project details






  Top   Research Information Center
 
Countries
Countries
  Algeria
  Argentina
  Australia
  Austria
  Bangladesh
  Belarus
  Belgium
  Benin
  Bolivia
  Botswana
  Brazil
  Bulgaria
  Burkina Faso
  Cambodia
  Cameroon
  Canada
  Cape Verde
  Chile
  China
  Colombia
  Costa Rica
  Croatia
  Cyprus
  Czech Republic
  Denmark
  Ecuador
  Egypt
  Estonia
  Ethiopia
  Faroe Islands
  Finland
  France
  Gambia
  Georgia

Countries
Countries
  Algeria
  Argentina
  Australia
  Austria
  Bangladesh
  Belarus
  Belgium
  Benin
  Bolivia
  Botswana
  Brazil
  Bulgaria
  Burkina Faso
  Cambodia
  Cameroon
  Canada
  Cape Verde
  Chile
  China
  Colombia
  Costa Rica
  Croatia
  Cyprus
  Czech Republic
  Denmark
  Ecuador
  Egypt
  Estonia
  Ethiopia
  Faroe Islands
  Finland
  France
  Gambia
  Georgia