The European Union (EU)-funded PEPCHIPOMICS project has developed a new technology which synthesises and analyses peptides in hundreds of thousands on a single microscope slide.
“The research team developed an innovative peptide ‘chip’ technology platform,” says project director, Professor Søren Buus of the University of Copenhagen, Denmark. “This allows more than one million different peptides to be synthesised on a surface the size of a postage stamp,” he adds.
“The innovative technology we developed significantly multiplies the number of peptides that can be handled and the range of concrete applications,” comments Dr. Claus Schafer-Nielsen, chief executive of Schafer-N, the Danish private-sector research organisation that worked with the PEPCHIPOMICS team.
These synthetic peptides are now being used for developing new vaccines, analysing the reactions of patients to infections from viruses, bacteria and parasites, and detecting traces of allergens – peanuts, hazel nuts and so on – in processed foods.
“The new technology not only increases the amount and quality of the information obtained, but also reduces the price per peptide by a factor of as much as 10,000,” concludes Dr. Schafer-Nielsen. The technology is expected to help the scientific community conduct further large-scale investigations into the overall functions and effects of proteins and peptides.