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  1. Reference materials for microbiology and pathogens

    The regular occurrence of food borne pathogen related outbreaks in the EU, the ongoing struggle with pathogens in health care and public health as well as the security threat related to the potential misuse of pathogens emphasise the need for an adequate ...

    02 September 2015

  2. Functional analysis of the integration host factor site of the sigma54 Pu promoter of Pseudomonas putida by in vivo UV imprinting

    The integration host factor (IHF) of Pseudomonas putida connects cell growth to transcriptional activity of distinct promoters. The IHF site of the sigma54 promoter Pu of the TOL (m-xylene biodegradation) plasmid pWW0 of P. putida has been examined to def ...

    01 December 2015

  3. Standardisation of Pluripotent Stem Cell Cultures for Toxicity Testing

    Introduction: Pluripotent stem cell (PSC) lines offer a unique opportunity to derive various human cell types which can be exploited for human safety assessments in vitro and as such contribute to modern mechanistically oriented toxicity testing. Areas co ...

    01 December 2015

  4. Molecular signatures induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells

    Using the Hey3Met2 human ovarian cancer cell line, we previously found the RNASET2 gene to possess a remarkable in vivo tumor suppressor activity, although no in vitro features such as inhibition of cell proliferation, clonogenic potential, impaired growt ...

    01 December 2015

  5. Comparison of therapeutic efficacy and biodistribution of 213Bi- and 211At-labeled monoclonal antibody MX35 in an ovarian cancer model

    Introduction: The purpose of this study was to compare the therapeutic efficacy and biodistribution of the monoclonal antibody MX35 labeled with either 213Bi or 211At, both α-emitters, in an ovarian cancer model. Methods: One hundred female nude BALB/c (n ...

    01 December 2015

  6. CCQM-K86/P113.1: Relative quantification of genomic DNA fragments from a biological tissue

    Key comparison CCQM-K86 was performed to demonstrate and document the capacity of interested national metrology institutes (NMIs) and designated institutes (DIs) in the determination of the relative quantity of two specific genomic DNA fragments present i ...

    01 December 2015

  7. Genomic and Phenotypic Alterations of the Neuronal-Like Cells Derived from Human Embryonal Carcinoma Stem Cells (NT2) Caused by Exposure to Organophosphorus Compounds Paraoxon and Mipafox

    Organophosphorus compounds (OPs) are pesticides of worldwide use due to the acute insecticidal effects mediated by the inhibition of esterases of the central nervous system (mainly acetylcholinesterase and neuropathy target esterase (NTE)). OPs need to in ...

    01 December 2015

  8. Analytical approaches for MCPD esters and glycidyl esters in food and biological samples: A review and future perspectives

    Esters of 2- and 3-monochloropropane-1,2-diol (MCPD) and glycidol esters are important contaminants of processed edible oils used as foods or food ingredients. This review describes the occurrence and analysis of MCPD esters and glycidol esters in vegetab ...

    01 December 2015

  9. Proficiency testing in analytical chemistry, microbiology and laboratory medicine: working discussions on current practice and future directions

    A summary of the working group (WG) discussions on proficiency testing (PT) and external quality assessment (EQA) held at the EURACHEM Workshop, Istanbul, 3–6 October 2011, is provided. The six WGs covered a range of issues concerned with current practice ...

    01 December 2015

  10. Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress.

    High content omic techniques in combination with stable human in vitro cell culture systems have the potential to improve on current pre-clinical safety regimes by providing detailed mechanistic information of altered cellular processes. Here we investiga ...

    01 December 2015

  11. An inter-laboratory validation of a multiplex dipstick assay for four classes of antibiotics in honey

    In this paper, we report the inter-laboratory validation (ILV) of a recently developed indirect competitive multiplex dipstick (Bee4sensor®) which is capable of the simultaneous detection of residues of some of the most frequently detected antibiotic resi ...

    01 December 2015

  12. What type of work are you involved in the cancer therapy research?

    The cancer research program at JRC-ITU focuses on all stages of developing targeted alpha therapy (TAT) from bench to bedside, including the development of innovative methods for the production of alpha emitters, pre-clinical studies in vitro and in vivo, ...

    30 April 2014