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  1. Public health

    Maintaining the highest possible level of public health protection, especially for an ageing population, is a key challenge for Europe in the changing global socio-economic landscape. Effective public health policies need to address a wide variety of comp ...

    02 September 2015

  2. Global health security and support

    The Global Health Security Initiative is an international partnership of the G7 countries (Canada, France, Germany, Italy, Japan, the United Kingdom and the United States), Mexico, the European Commission and the World Health Organisation (WHO) to strengt ...

    01 September 2015

  3. Medical applications of radionuclides and targeted alpha therapy

    Cancer is one of the main health problems of today. Unfortunately, the treatments that are currently available, even though often effective, cannot permanently cure the majority of cancers. This is typically true for cancers that have formed metastases an ...

    01 September 2015

  4. Reference materials for clinical analysis

    The measurement of biomarkers, mainly in blood, is performed in many thousands of hospital laboratories.  The results are used to monitor health status, screen for disease, support diagnosis, and monitor the effect of therapies for diseases. However, meas ...

    02 September 2015

  5. Human exposure

    A person is exposed to many environmental factors within his/her local environment: chemical emissions from consumer products (particles, air pollutants), environmental noise, molds etc.. These chemical, physical, and biological factors play an important ...

    01 September 2015

  6. Healthcare quality

    Healthcare quality is the extent to which health services provided to individuals and patient populations improve desired health outcomes. Care should be evidence-based and provided in a technically and culturally competent manner with good communication ...

    02 September 2015

  7. Nutrition

    Eating habits can go a long way towards ensuring good health. Low consumption of fruits, vegetables or fibre, and excess intakes of salt, sugars, and trans and saturated fats are among the top contributors to death and disability caused by non-communicabl ...

    02 September 2015

  8. Treatment of experimental pancreatic cancer with 213-Bismuth-labeled chimeric antibody to single-strand DNA in combination with cisplatin and gemcitabine

    Pancreatic cancer (PCa), the 4th leading cause of cancer deaths, has a notoriously poor prognosis with the 5-year survival rate of only 4%. Novel approaches to its treatment are urgently needed. A chimeric monoclonal antibody (mAb) chTNT3 binds to single- ...

    28 June 2013

  9. Alpha particles induce anti-tumour immunity

    The aim of this investigation is to determine whether irradiation of tumours with alpha radiation can foster an anti-tumour immune response. GORIN J, MÉNAGER Jérémie, GOUARD S., MAUREL C, CHEREL M., FAIVRE-CHAUVET A, MORGENSTERN Alfred, BRUCHERTSEIFER Fra ...

    28 June 2013

  10. DNA double strand break assessment by yH2AX-foci quantification after alpha-particle emitter Ac-225 and electron emitter Lu-177 somatostatin receptor targeted radiotherapy correlates with cell death and apoptosis in vitro

    Alpha-particle emitters display high linear energy transfer combined with short range and are promising for treatment of metastasized tumors. Indeed, efficiency and high specificity of tumor-specific antibodies labelled with alpha emitting nuclides were d ...

    27 June 2013

  11. 213-Bismuth-labeled antibody to gp41 glycoprotein kills ART-treated lymphocytes from HIV patients and HIV-infected monocytes in human blood brain barrier model

    Eliminating virally infected cells is an essential component of HIV eradication strategy. In addition, many patients on antiretroviral therapy (ART) suffer from HIV-associated neurocognitive disorders because the brain becomes a reservoir for infection. T ...

    27 June 2013

  12. An Alpha-Particle Emiting Radiopeptide (213 Bi-DOTA-PESIN) for Therapy of Prostate Cancer

    Recurrent prostate cancer presents a challenge to conventional treatment, particularly so to address micrometastatic and small-volume disease. Use of a-radionuclide therapy is considered as a highly effective treatment in such applications due to the shor ...

    26 October 2011

  13. TBTC induces adipocyte differentiation in human bone marrow long term culture

    Organotins are widely used in agriculture and in chemical industry, causing persistent and widespread pollution. Organotins may affect the brain, liver and immune system and eventually human health. Recently, it has been shown that tributyltin (TBT) inter ...

    26 October 2011

  14. Autofluorescence microscopy: a non-destructive tool to monitor mitochondrial morphology and toxicity

    Visualization of NADH by fluorescence microscopy makes it possible to distinguish mitochondria inside living cells allowing structure analysis of these organelles in a noninvasive way. Mitochondrial morphology is determined by the occurrence of mitochondr ...

    04 November 2011

  15. Selective inhibition of B lymphocytes in TBTC-treated human bone marrow long-term culture

    Tributyltin chloride (TBTC) is well known for its immunotoxic effect, in particular towards immature thymocytes. TBTC is also known to induce adipocyte differentiation in primary human bone marrow cultures, which is reflected in the decrease in a number o ...

    04 November 2011

  16. Application of the Modular Approach to an In-House Validation Study of Real-Time PCR Methods for the Detection and Serogroup Determination of Verocytotoxigenic Escherichia coli

    European Commission regulation 2073/2005 on the microbiological criteria for food requires that Escherichia coli is monitored as an indicator of hygienic conditions. Since verocytotoxigenic E. coli (VTEC) strains often cause food-borne infections by the c ...

    04 November 2011

  17. Investigating the influence of data splitting on the predictive ability of QSAR/QSPR models

    The study was aimed at investigating how the method of splitting data into a training set and a test set influences the external predictivity of quantitative structure-activity and/or structure-property relationships (QSAR/QSPR) models. Six models of good ...

    04 November 2011

  18. icoshift: an effective tool for the alignment of chromatographic data

    The interval Correlation Optimised shifting algorithm (icoshift) has recently been introduced for the alignment of nuclear magnetic resonance spectra. The method is based on an insertion/deletion model to shift intervals of spectra/chromatograms and relie ...

    04 November 2011

  19. Photocatalytic degradation of organic paint constituents-formation of carbonyls

    Titanium dioxide is frequently used in outdoor building materials to degrade, when activated by solar light, organic and inorganic pollutants in air. In this context, a promising application is the use of TiO2 in photo-catalytic paints. The development of ...

    04 November 2011

  20. A mesenchymal stromal cell line resistant to paclitaxel that spontaneously differentiates into osteoblast-like cells

    The mesenchymal stromal cell line SR- 4987 has been established in our laboratory from the bone marrow of BDF/1 mice. Recent information on mesenchymal stem cells biology and the need to deal with well-characterized cell lines suggest to critically consid ...

    05 November 2011

  21. The H1N1 (2009) influenza pandemic: insights into its dynamics from different types of epidemiological data

    For the assessment of the transmission potential and the severity of the recent H1N1 (2009) influenza pandemic, a series of different types of epidemiological data were used. We describe the way these data have been employed to estimate some key epidemiol ...

    09 November 2011

  22. Targeted alpha therapy with 213Bi

    The potential of targeted therapy with the alpha emitter 213Bi has been successfully demonstrated in a large number of preclinical studies and several clinical trials have provided evidence for its feasibility, safety and therapeutic efficacy. This review ...

    12 November 2011

  23. Highlights on environmental noise and health research in Central and Eastern Europe, South-East Europe and Newly Independent States

    The adverse effects of noise on health have been intensely explored in the previous fifty years. However, the scope of research conducted in Central and Eastern European countries (CEE), South-East European countries (SEE) and Newly Independent States (NI ...

    09 November 2011

  24. Unprecedented Incorporation of alpha-Emitter Radioisotope 213Bi into Porphyrin Chelates with Reference to a Daughter Isotope Mediated Assistance Mechanism

    For the first time, alphaemitter radioisotope 213Bi has been 10 incorporated into porphyrin chelates, with rates matching with the short period of the radionuclide. An in-situ transmetalation mechanism involving the daughter isotope 209Pb is expected to ...

    12 November 2011

  25. Empowering patients through ICT – organisational impact on healthcare systems in England and Scotland

    This paper reports on the efforts carried out by England and Scotland to promote the widespread use of telehealthcare within Personal Health Systems (PHS) for patients with chronic conditions. In each setting, it explains the political drive, the trends i ...

    15 November 2011