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  1. Determination of brominated flame retardants: a proficiency test

    JRC conference contribution presenting the results of a proficiency test for the determination of total bromine and several polybrominated biphenyls and diphenyl ethers (PBB and PBDE) in plastic. This manuscript presents the results of a proficiency test ...

    30 April 2014

  2. IMEP-34: Heavy Metals in Toys according to EN 71-3:1994

    JRC Scientific and Technical Research Report presenting the results of an  interlaboratory comparison (ILC) which focussed on the determination of soluble antimony (Sb), arsenic (As), barium (Ba), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg), and ...

    30 April 2014

  3. Determination of semduramicin in poultry feed additive, premixture and compound feed by liquid chromatography and UV spectrophotometric detection after post-column derivatisation

    JRC article in journal describing a method for the determination of semduramicin in poultry compound feed, premixtures and feed additive as well as its discrimination from other coccidiostats in poultry compound feed. A new, simple and fit for purpose met ...

    30 April 2014

  4. Chapter 3: Analytical Quality Assurance

    A JRC authored book chapter providing an overview which covers basic aspects relevant to quality with a special focus on analytical quality in the field of food analysis. Thousands of analytical measurements are performed every day in food laboratories al ...

    30 April 2014

  5. Standardisation of Pluripotent Stem Cell Cultures for Toxicity Testing

    Article dealing with the standardisation of pluripotent stem cell (PSC) lines, which offer a unique opportunity to derive various human cell types which could be exploited for a more efficient selection of drug candidates as well as for mechanistically or ...

    30 April 2014

  6. Programme of pre-accession assistance "Improving Chemical and Ionising Radiation Metrology" in Turkey- Fourth Interim Report

    JRC Scientific and Technical Research Report providing  an overview on progress of the project Europe and Metrology in Turkey (EMIT). The aim of the project is to contribute to the better functioning of the EU-Turkey Customs Union Agreement. The report re ...

    30 April 2014

  7. From the packet to the pan: keeping harmful chemicals out of your food

    Examples of JRC research making the life of Europe's citizens safer and more secure in the area of food safety. (2009) 2009 Leaflets Health and consumer protection food/feed safety quality chemical IHCP IRMM jrc_leaflet_food_materials_de.pdf jrc_leaf ...

    30 April 2014

  8. CFD Modelling of Gas-Transport and Mixing Phenomena in the Batelle Experimental Facility for Nuclear Safety Applications

    This paper describes the results of CFD (Computational Fluid Dynamics) analysis of jet release, dispersion and mixing phenomena of light gases in nuclear environments for safety applications. A validation exercise with three CFD codes (CFX4, CFX5.7 and CD ...

    30 April 2014

  9. Search for a more adequate test to predict the long-term migration from the PVC gaskets of metal lids into oily foods in glass jars

    As shown previously, the conventional testing procedure for simulating long-term migration from the gaskets of metal closures into oily foods does not adequately reflect reality. It appears to be impossible to accelerate migration to the extent that the s ...

    30 April 2014

  10. Investigating the influence of data splitting on the predictive ability of QSAR/QSPR models

    The study was aimed at investigating how the method of splitting data into a training set and a test set influences the external predictivity of quantitative structure-activity and/or structure-property relationships (QSAR/QSPR) models. Six models of good ...

    30 April 2014

  11. Recent Advances in the Molecular Modeling of Estrogen Receptor-Mediated Toxicity

    In the past two decades there has been increasing concern about the potentially adverse effects of exogenous Endocrine Active Substances (EAS) that alter the function of the endocrine system by interfering with hormone regulation. The mechanistic pathways ...

    30 April 2014

  12. Validation of Dynamic Light Scattering and Centrifugal Liquid Sedimentation Methods for Nanoparticle Characterisation

    A variety of techniques exists to analyse the size and size distribution of nanoparticles in a suspension. However, neither full method validation reports nor suitable reference materials with properly assigned values traceable to SI are easily found in t ...

    30 April 2014

  13. Autofluorescence microscopy: a non-destructive tool to monitor mitochondrial morphology and toxicity

    Visualization of NADH by fluorescence microscopy makes it possible to distinguish mitochondria inside living cells allowing structure analysis of these organelles in a noninvasive way. Mitochondrial morphology is determined by the occurrence of mitochondr ...

    30 April 2014

  14. Protein and lipid binding parameters in rainbow trout (Oncorhynchus mykiss) blood and liver fractions to extrapolate from an in vitro metabolic degradation assay to in vivo bioaccumulation potential of hydrophobic organic chemicals

    Binding of hydrophobic chemicals to colloids such as proteins or lipids is difficult to measure using classical microdialysis methods due to low aqueous concentrations, adsorption to dialysis membranes and test vessels, and slow kinetics of equilibration. ...

    30 April 2014

  15. Functional analysis of the integration host factor site of the sigma54 Pu promoter of Pseudomonas putida by in vivo UV imprinting

    The integration host factor (IHF) of Pseudomonas putida connects cell growth to transcriptional activity of distinct promoters. The IHF site of the sigma54 promoter Pu of the TOL (m-xylene biodegradation) plasmid pWW0 of P. putida has been examined to def ...

    30 April 2014

  16. How accurate are electronic structure methods for actinoid chemistry?

    The CASPT2, CCSD, and CCSD(T) levels of wave function theory and seven density functionals were tested against experiment for predicting the ionization potentials and bond dissociation energies of actinoid monoxides and dioxides with their cations. The go ...

    30 April 2014

  17. Background Paper on Sources and Occurrence of Bisphenol A Relevant for Exposure of Consumers

    The Expert Meeting considered BPA concentrations in food from food surveys and BPA migration from food contact and dental materials. BPA concentrations in air, dust and water were also considered. The Expert Meeting noted that by far the majority of studi ...

    30 April 2014

  18. AUTOMATION OF AN IN VITRO CITOTOXICITY ASSAY USED TO ESTIMATE- STARTING DOSES IN ACUTE ORAL SYSTEMIC TOXICITY TESTS

    The development, optimisation and validation of alternative methods that can be used for regulatory safety assessment is a challenging endeavour. Moreover, the demand for reliable and relevant tests that can be widely deployed has never been greater. New ...

    30 April 2014

  19. Preface to mutation research special issue on cell transformation

    No abstract is needed for this paper which represents the preface to the special issue in Mutation Research on cell transformation VANPARYS Phillippe CORVI Raffaella 2012 Articles in Journals Institute for Health and Consumer Protection Health and consume ...

    30 April 2014

  20. Numerical and Experimental Methodology for the Development of a New Membrane Prototype Intended to Microfiltration Bioprocesses. Application to Milk Filtration

    In tangential flow filtration, the non-uniform TransMembrane Pressure (TMP) on the membrane length produces a non homogeneous filtration cake, initiates process selectivity changes and modifies the permeate quality. The purpose of this study is to create ...

    30 April 2014

  21. Plasticisers in poly(vinyl chloride) gasket seals and in food matrixes: food safety implications and analytical solutions by mass spectrometry

    Lids seal against the glass rim with gaskets consisting of plasticized PVC and represent an issue as migration of plasticizers from these gaskets into foods. The plastisols used typically contain 25?45% plasticizer, frequently epoxidized soy bean oil and ...

    30 April 2014

  22. Proficiency testing in analytical chemistry, microbiology and laboratory medicine: working discussions on current practice and future directions

    A summary of the working group (WG) discussions on proficiency testing (PT) and external quality assessment (EQA) held at the EURACHEM Workshop, Istanbul, 3?6 October 2011, is provided. The six WGs covered a range of issues concerned with current practice ...

    30 April 2014

  23. Report on the International Workshop on Alternative Methods for Human and Veterinary Rabies Vaccine Testing: State of the Science and Planning the Way Forward

    Potency testing of most human and veterinary rabies vaccines requires vaccination of mice followed by a challenge test using an intracerebral injection of live rabies virus. The National Toxicology Program Interagency Center for the Evaluation of Alternat ...

    30 April 2014

  24. Nanotechnology in manufacturing paints for eco-efficient buildings

    The addition of a photocatalyst provides decontamination properties to a paint. It is able of continuously oxidizing both organic and inorganic pollutants and microorganisms under the influence of light. Photocatalytic paints are useful in a wide range of ...

    30 April 2014

  25. Training needs for toxicity testing in the 21st century: a survey-informed analysis

    Current and future training needs on the use of alternative methods in predictive toxicology, including new approaches based on mode of action (MOA) and adverse outcome pathway (AOP) concepts, are expected to evolve rapidly. In order to gain insight into ...

    30 April 2014