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  1. Alternatives to animal testing and safety assessment of chemicals

    Chemical safety assessment has traditionally been based on animal testing but the EU has been promoting for many years the replacement, reduction, and refinement of animal testing. Further it is also considered that traditional risk assessment approaches ...

    29 June 2016

  2. Assessing potential risks from exposure to chemical mixtures- case study review

    08 Jul 2016 A review of case studies assessing the risk from exposure to chemical mixtures shows a potential concern for several groups of chemicals for highly exposed or particularly vulnerable population groups. Humans and wildlife can be exposed to an ...

    08 July 2016

  3. Launch of research project "VAC2VAC" to develop animal-free methods for the quality control of vaccines

    04 Jul 2016 The new VAC2VAC project- "Vaccine batch to vaccine batch comparison by consistency testing" – officially launched on the 1st March 2016, brings together 20 public and private partners including the European Commission Joint Research ...

    04 July 2016

  4. A cross-sector review of the demand for in vivo carcinogenicity studies

    29 Jun 2016 The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) of the European Commission's Joint Research Centre releases its report reviewing the current demand for in vivo carcinogenicity studies across chemica ...

    29 June 2016

  5. Summary records available for the meeting of EURL ECVAM with its stakeholders and regulatory advisory network

    21 Jun 2016 The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) has published the summary records for the meetings which took place with the members of the Preliminary Assessment of Regulatory Relevance (PARERE) network ...

    21 June 2016

  6. EURL ECVAM hosts meeting of European 3Rs Centres

    08 Jun 2016 From 31 May to 1 June 2016, the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) of the European Commission's Joint Research Centre hosted a second meeting of European 3Rs Centres at the JRC site in Ispr ...

    08 June 2016

  7. EURL ECVAM training on modern toxicological sciences

    31 May 2016 On 18-19 May 2016 EURL ECVAM ran a training course on "Basic knowledge in modern toxicological sciences" designed for students of Master’s programmes of Toxicology.  23 students from 12 different countries participated in the course ...

    31 May 2016

  8. Avoiding chronic fish toxicity testing

    17 May 2016 The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) of the European Commission's Joint Research Centre has just released its report presenting scientific options for avoiding chronic fish testing on the ...

    17 May 2016

  9. Cosmetics Europe compilation of historical serious eye damage/eye irritation in vivo data analysed by drivers of classification to support the selection of chemicals for development and evaluation of alternative methods/strategies: the Draize eye test Ref

    A thorough understanding of which of the effects assessed in the in vivo Draize eye test are responsible for driving UN GHS/EU CLP classification is critical for an adequate selection of chemicals to be used in the development and/or evaluation of alterna ...

    15 July 2016

  10. In silico models for acute systemic toxicity

    In this book chapter, we give an overview of the regulatory requirements for acute systemic toxicity information in the European Union, and we review the availability of structure-based computational models that are available and potentially useful in the ...

    15 July 2016

  11. Review of case studies on the human and environmental risk assessment of chemical mixtures

    Humans and wildlife can be exposed to an infinite number of different combinations of chemicals in mixtures via food, consumer products and the environment, which might impact health. The number of chemicals and composition of chemical mixtures one might ...

    30 June 2016

  12. Analysis of carcinogenicity testing for regulatory purposes in the European Union

    The approaches for evaluating the carcinogenic potential of substances, including whether carcinogenicity studies should be conducted, differ substantially across sectors. Despite variations in testing schemes, the two-year bioassay study in rodents repre ...

    30 June 2016

  13. EU-NETVAL welcomes new member facilities

    17 Mar 2016 The European Union Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) was set up by EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) in response to the provision of Directive 2010/63/EU on the ...

    17 March 2016

  14. EURL ECVAM GLP Test Facility

    EURL ECVAM GLP Test Facility http://ihcp.jrc.ec.europa.eu/our_labs/eurl-ecvam/laboratories-research/glp-test-... The EURL ECVAM GLP Test Facility is responsible for the execution of validation studies that establish the reliability and relevance of in vit ...

    30 April 2014

  15. High Throughput Screening facility

    hts http://ihcp.jrc.ec.europa.eu/our_labs/hts The IHCP High Throughput Screening (HTS) facility consists of two comprehensive robotic platforms supported by ample cell culturing and compound management laboratories. The robotic platform is a flexible, mod ...

    30 April 2014

  16. SEURAT: Safety Evaluation Ultimately Replacing Animal Testing – Recommendations for future research in the field of predictive toxicology

    The development of non-animal methodology to evaluate the potential for a chemical to cause systemic toxicity is one of the grand challenges of modern science. The European research programme SEURAT is active in this field and will conclude its first phas ...

    19 June 2016

  17. Screening methodology to identify potential endocrine disruptors according to different options in the context of an impact assessment

    Several pieces of EU legislation regulate the marketing and use of chemical substances. While several regulations, including the regulations on Plant Protection Products (PPPR), Biocidal Products (BPR) and Chemicals (REACH), include provisions for endocri ...

    17 June 2016

  18. Alternatives to animal testing- EU public survey launched

    01 Feb 2016 Following the European Commission's Communication published in response to the European Citizens' Initiative "Stop Vivisection", the JRC's Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) has launch ...

    01 February 2016

  19. Assessing performance of new or improved genotoxicity tests: EURL ECVAM publishes an updated recommended list of reference chemicals

    17 Dec 2015 Reference chemical selection is a key step in the development, optimisation and validation of alternative test methods. In light of newly available data, the JRC's European Union Reference Laboratory for Alternatives to Animal Testing (EU ...

    17 December 2015

  20. Analysis of the Local Lymph Node Assay (LLNA) variability for assessing the prediction of skin sensitisation potential and potency of chemicals with non-animal approaches

    The knowledge of the biological mechanisms leading to the induction of skin sensitisation has favoured in recent years the development of alternative non-animal methods. During the formal validation process, results from the Local Lymph Node Assay (LLNA) ...

    13 May 2016

  21. “Watching the Detectives” report of the general assembly of the EU project DETECTIVE Brussels, 24–25 November 2015

    SEURAT-1 is a joint research initiative between the European Commission and Cosmetics Europe aiming to develop in vitro- and in silico-based methods to replace the in vivo repeated dose systemic toxicity test used for the assessment of human safety. As on ...

    08 June 2016

  22. A global approach towards alternatives to animal testing

    17 Nov 2015 Members of the International Cooperation on Alternative Test Methods attended a two-day meeting hosted by the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) on 10-11 November 2015 at the JRC's Ispra si ...

    17 November 2015

  23. ChemAgora Portal

    ChemAgora http://chemagora.jrc.ec.europa.eu/chemagora/ The ChemAgora portal provides a fast lane to chemical information available online on a certain chemical substance. Chemicals can be searched by their name, (also partial), CAS Registration number, In ...

    21 October 2014

  24. The Adverse Outcome Pathway: A Conceptual Framework to Support Toxicity Testing in the Twenty-First Century

    The need to rapidly characterize the risk of large numbers of chemicals has moved the traditional toxicological paradigm from animal testing to a pathway-based approach using in vitro assay systems and modeling where possible. Adverse Outcome Pathways (AO ...

    17 April 2016

  25. Assessing the combined effects of chemicals using non-animal methods

    20 Oct 2015 Novel, non-animal tools and scientific methodologies show high potential for the assessment of combined effects of chemicals on humans and the environment. They allow meaningful information on individual mixture components or whole mixtures to ...

    20 October 2015