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  1. Alternatives to animal testing and safety assessment of chemicals

    Chemical safety assessment has traditionally been based on animal testing but the EU has been promoting for many years the replacement, reduction, and refinement of animal testing. Further it is also considered that traditional risk assessment approaches ...

    30 April 2014

  2. EU-NETVAL welcomes new member facilities

    17 Mar 2016 The European Union Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) was set up by EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) in response to the provision of Directive 2010/63/EU on the ...

    17 March 2016

  3. Alternatives to animal testing- EU public survey launched

    01 Feb 2016 Following the European Commission's Communication published in response to the European Citizens' Initiative "Stop Vivisection", the JRC's Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) has launch ...

    01 February 2016

  4. The Adverse Outcome Pathway: A Conceptual Framework to Support Toxicity Testing in the Twenty-First Century

    The need to rapidly characterize the risk of large numbers of chemicals has moved the traditional toxicological paradigm from animal testing to a pathway-based approach using in vitro assay systems and modeling where possible. Adverse Outcome Pathways (AO ...

    17 April 2016

  5. Adverse Outcome Pathways for Regulatory Applications: Examination of Four Case Studies With Different Degrees of Completeness and Scientific Confidence

    Adverse outcome pathways (AOPs) offer a pathway-based toxicological framework to support hazard assessment and regulatory decision-making. However, little has been discussed about the scientific confidence needed, or how complete a pathway should be, befo ...

    10 April 2016

  6. EURL ECVAM GLP Test Facility

    EURL ECVAM GLP Test Facility http://ihcp.jrc.ec.europa.eu/our_labs/eurl-ecvam/laboratories-research/glp-test-... The EURL ECVAM GLP Test Facility is responsible for the execution of validation studies that establish the reliability and relevance of in vit ...

    30 April 2014

  7. High Throughput Screening facility

    hts http://ihcp.jrc.ec.europa.eu/our_labs/hts The IHCP High Throughput Screening (HTS) facility consists of two comprehensive robotic platforms supported by ample cell culturing and compound management laboratories. The robotic platform is a flexible, mod ...

    30 April 2014

  8. Assessing performance of new or improved genotoxicity tests: EURL ECVAM publishes an updated recommended list of reference chemicals

    17 Dec 2015 Reference chemical selection is a key step in the development, optimisation and validation of alternative test methods. In light of newly available data, the JRC's European Union Reference Laboratory for Alternatives to Animal Testing (EU ...

    17 December 2015

  9. Procedures for the reconstruction, primary culture and experimental use of rainbow trout gill epithelia

    This protocol describes how to reconstruct and culture the freshwater rainbow trout gill epithelium on flat permeable membrane supports within cell culture inserts. The protocol describes gill cell isolation, cultured gill epithelium formation, maintenanc ...

    20 March 2016

  10. A global approach towards alternatives to animal testing

    17 Nov 2015 Members of the International Cooperation on Alternative Test Methods attended a two-day meeting hosted by the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) on 10-11 November 2015 at the JRC's Ispra si ...

    17 November 2015

  11. Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity

    Statistical-based and expert rule-based models built using public domain mutagenicity knowledge and data are routinely used for computational (Q)SAR assessments of pharmaceutical impurities in line with the approach recommended in the ICH M7 guideline. Kn ...

    09 March 2016

  12. Ability of non-animal methods for skin sensitisation to detect pre- and pro-haptens: Report and recommendations of an EURL ECVAM expert meeting

    Significant progress has been made in the development, validation and regulatory acceptance of in chemico and in vitro test methods for skin sensitisation. Although these methods have been shown to perform relatively well (about 80% accuracy in predicting ...

    28 February 2016

  13. Seurat-1: HepaRG, repeated and single dose exposure for Mitochondrial Health and LipidTox

    The purpose of this report is to describe the experimental procedure used in order to detect changes in mitochondrial membrane potential and lipid accumulation following exposure of HepaRG cells to various chemicals both by repeated exposure as single exp ...

    04 March 2016

  14. Assessing the combined effects of chemicals using non-animal methods

    20 Oct 2015 Novel, non-animal tools and scientific methodologies show high potential for the assessment of combined effects of chemicals on humans and the environment. They allow meaningful information on individual mixture components or whole mixtures to ...

    20 October 2015

  15. EURL ECVAM’s Status Report 2015 published

    14 Oct 2015 The  Status Report  published by EURL ECVAM (the European Union Reference Laboratory for Alternatives to Animal Testing) on 14 October provides an update on the development, validation and regulatory acceptance of alternative methods/approache ...

    14 October 2015

  16. JRC supports identification of substances of very high concern under REACH

    28 Aug 2015 New JRC report helps identifying substances that might need to be considered within the European chemicals regulation REACH as potentially causing serious effects on human health and the environment. It analyses whether substances known to cau ...

    28 August 2015

  17. In Vitro Toxicology Systems book shortlisted for a Lush Prize 2015

    25 Aug 2015 Co-edited and co-authored by ECVAM scientists, the "In Vitro Toxicology Systems" book has been shortlisted for this year's Lush Prize in the training category. It brings together important issues and considerations needed in ord ...

    25 August 2015

  18. ChemAgora Portal

    ChemAgora http://chemagora.jrc.ec.europa.eu/chemagora/ The ChemAgora portal provides a fast lane to chemical information available online on a certain chemical substance. Chemicals can be searched by their name, (also partial), CAS Registration number, In ...

    21 October 2014

  19. JRC database now provides non-guideline in vitro test methods in OECD compliant format

    18 Aug 2015 The JRC's European Union Reference Laboratory for Alternative Methods to Animal Testing (EURL ECVAM) has adapted the format of DB-ALM, its unique public database on alternative methods, to fully comply with the OECD guidance for describin ...

    18 August 2015

  20. New strategy to track how chemicals behave in the human body

    14 Jul 2015 Information on how a chemical enters, moves and behaves throughout its journey inside the human body is crucial in the assessment of its safety. Such data is traditionally obtained through animal-based test procedures. The JRC-run EU Reference ...

    14 July 2015

  21. Use of HPLC/UPLC-spectrophotometry for detection of formazan in in vitro Reconstructed human Tissue (RhT)-based test methods employing the MTT-reduction assay to expand their applicability to strongly coloured test chemicals

    A number of in vitro test methods using Reconstructed human Tissues (RhT) are regulatory accepted for evaluation of skin corrosion/irritation. In such methods, test chemical corrosion/irritation potential is determined by measuring tissue viability using ...

    17 January 2016

  22. Chemical Lists Information System

    CheLIST Chemical Lists Information System In order to develop and assess computational and in vitro methods for predictive toxicology, there is a need to identify chemicals for which property data are available. The Chemical Lists Information System provi ...

    03 June 2014

  23. Replacement, Reduction and Refinement of Animal Testing in the Quality Control of Human Vaccines

    Vaccines are recognised as a highly cost effective tool for preventing infectious diseases. They are derived from biological sources and due to the complexity of composition and heterogeneity of products, vaccine lots undergo legally required quality cont ...

    21 January 2016

  24. Commission replies to European Citizens' Initiative against animal testing

    03 Jun 2015 The European Commission today issued a Communication in response to the European Citizens’ Initiative Stop Vivisection. While sharing the conviction that animal testing should be phased out in Europe, the Commission considers it premature to r ...

    03 June 2015

  25. European Union Network of Laboratories for the Validation of Alternative Methods

    EU-NETVAL EU-NETVAL EU-NETVAL provides support for EURL ECVAM's validation studies that serve to assess the reliability and relevance of alternative methods with a potential to replace, reduce, or refine the use of animals for scientific purposes. It ...

    30 April 2014