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Publication Year: 
2016
JRC Publication N°: 
JRC101583
Authors: 
ZALDIVAR COMENGES Jose'
JOOSSENS Elisabeth
SALA BENITO Jose'
WORTH Andrew
PAINI Alicia
Publication Year: 
2017
JRC Publication N°: 
JRC105769
Authors: 
SALA BENITO Jose'
PAINI Alicia
RICHARZ Andrea
MEINL Thorsten
BERTHOLD M
CRONIN Mark
WORTH Andrew
Publication Year: 
2016
JRC Publication N°: 
JRC103486
Authors: 
PAINI Alicia
MENNECOZZI Milena
HORVAT Tomislav
GERLOFF Kirsten Britta
PALOSAARI Taina
SALA BENITO Jose'
WORTH Andrew
Meeting of the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) 10-11th October 2017 Meeting of the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) 10-11th October 2017
©EU, 2017
Oct 13 2017

EU-NETVAL is a large network of highly qualified test facilities across Europe, coordinated by the Joint Research Centre to support the in vitro method validation process.

Publication Year: 
2017
JRC Publication N°: 
JRC106566
Authors: 
CORVI Raffaella
MADIA Federica
GUYTON Kathryn Z.
KASPER Peter
RUDEL Ruthann
COLACCI Annamaria
KLEINJANS Jos
JENNINGS Paul
Human iPSC-derived neuronal cells (stained for β-III-Tubulin) after 21 days of differentiation Human iPSC-derived neuronal cells (stained for β-III-Tubulin) after 21 days of differentiation
©EU, 2017
Oct 17 2017

JRC scientists have shown that human induced pluripotent stem cell-derived neurons are suitable non-animal models for testing neurotoxicity during brain development. The study revealed that long term exposure to the pesticide rotenone induces oxidative stress and can trigger neuronal cell death.

Expert workshop to capture inflammatory processes within the Adverse Outcome Pathway framework Expert workshop to capture inflammatory processes within the Adverse Outcome Pathway framework
©EU, 2017
Oct 03 2017

The European Commission’s Joint Research Centre (JRC) in Ispra hosted a two day workshop on 27-28th September 2017 to address how the complex and dynamic processes of inflammation could be integrated within the context of the Adverse Outcome Pathway (AOP) framework. This will contribute to the ongoing work to accelerate progress in the development of non-animal test methods.

Recommendations to delete or replace animal tests for quality control of biologicals Recommendations to delete or replace animal tests for quality control of biologicals
©EU, 2017
Oct 13 2017

International experts,  including JRC scientists,  recommend as outcome of special workshop the deletion or replacement of specific animal tests for the quality control of medicinal products, in particular biologicals (e.g. hormones, vaccines, immunoglobulins, blood products).

Chemical safety assessment with computational models of the skin Chemical safety assessment with computational models of the skin
©naturwohl-gesundheit – Pixabay.com
Sep 22 2017

JRC scientists contributed to the review of in silico models that have been developed for the prediction of skin permeability. Such models are relevant for the implementation of EU legislation on chemicals that strongly recommend or require the use of alternative approaches to animal studies.

Multi-walled Carbon Nanotube Multi-walled Carbon Nanotube
©Eric Wieser - Wikimedia Commons
Sep 29 2017

JRC scientists have reviewed the current status and potential applicability of computational methods for predicting the properties of engineered nanomaterials, especially in view of EU chemicals legislation (in particular REACH). The outcome of the study revealed that considerable scientific progress has been made,  although challenges remain in translating these developments into regulatory practice.

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