EU Science Hub

Scientific tools & databases

The range of work carried out at the JRC includes the

  • compilation of databases
  • development of software and modelling tools

On the basis of our open data principles we publish tools and databases with clear descriptions for each entry here on the Science Hub.

The tools and databases are categorised by name and acronym, but can be filtered by research area, keyword and JRC institute responsible for the coordination of the particular entry. 

To search specific datasets or collections, the JRC Data Catalogue opens access to our data.

The Central Core DNA Sequence Information System (CCSIS) is an implementation of a DNA sequence database integrated with bioinformatics tools to give support to the European Union Reference Laboratory for Genetically Modified Food & Feed (EU-RL GMFF) as foreseen by the Commission Regulation (EC) No 641/2004.


The ChemAgora portal provides a fast lane to chemical information available online on a certain chemical substance.

Chemicals can be searched by their name, (also partial), CAS Registration number, InChIKey or chemical structure (by drawing the molecule in an appropriate editor).

Once either of these search criteria is entered, the JRC service searches through a series of public repositories and offers clickable links to the exact pages where more information about the chemical can be found. 


The Chemical Reactivity and Fate Tool (CRAFT) allows the user to evaluate the chemical reactivity, persistence, biodegradation and fate of chemical compounds in the environment.

The Metabolic Information Input System Editor (METIS) is designed for the storage and input of information on metabolic pathways and degradation reactions in the database employed by CRAFT software.


DART (Decision Analysis by Ranking Techniques) is a powerful and user-friendly software tool designed for the ranking of chemicals according to their environmental and toxicological concern based on the most recent ranking theories.

Different kinds of order ranking methods, roughly classified as total (also called even-scoring) and partial-order ranking methods (Hasse diagram technique), are implemented in DART. These methods can be used to rank chemicals on the basis of more than one variable.


The purpose of the GMOINFO system is to publish information regarding notifications submitted from the applicants to the Member States Competent Authorities about deliberate field trials and placing on the market for cultivation, food, feed and processing, of genetically modified organisms, as defined in Directive 2001/18/EC of the European Parliament and of the Council of 12 March 2001.

Collaborating DGs: 
DG Health and Food Safety
The Endocrine Active Substances Information System (EASIS) is a database of studies related to chemicals that are considered to have endocrine activity.
Collaborating DGs: 

EURL ECVAM Database on Alternative Methods to Animal Experimentation (DB-ALM) is a publicly accessible collection of alternative method summaries and protocols.

It focuses primarily on methods submitted to EURL ECVAM for validation, and those identified in ad hoc reviews of the literature and end-users in specific application areas between 2000 and 2019.

The EURL ECVAM Genotoxicity and Carcinogenicity Consolidated Database is a database that compiles available genotoxicity and carcinogenicity data relating to chemicals that are Ames positive.

The EURL ECVAM Search Guide provides search principles and procedures, suggested search terms and user guidance together with an inventory of information resources to support untrained database users in finding information on relevant alternative strategies and methods on the Internet.

Developed by the JRC's EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), the Search Guide was first published as a handbook in 2012 by the EU Bookshop.

The EURL ECVAM Tracking System for Alternative methods towards Regulatory acceptance (TSAR) provides an overview of alternative (non-animal) methods that have been proposed for regulatory safety or efficacy testing of chemicals or biological agents such as vaccines.

It tracks the progress from submission of an alternative method for validation through to its final adoption by inclusion into the regulatory framework.