We are doing science for policy
The Joint Research Centre (JRC) is the European Commission's science and knowledge service which employs scientists to carry out research in order to provide independent scientific advice and support to EU policy.
JRC scientists have explored the application of Adverse Outcome Pathways (AOP) to improve mechanistic understanding of human disease pathophysiology in order to advance biomedical research and inform the development of new drugs.
The AOP concept was originally developed to facilitate better use of mechanistic understanding in determining the toxicological properties of chemicals.
In particular, the goal has been to deliver reliable, animal-free methodologies for the hazard and risk assessment of chemicals, making greater use of in vitro and in silico methods.
The outcome of a workshop reviewing progress in carcinogenicity assessment of chemicals has been published in the latest issue of Toxicology in Vitro Special Issue. The workshop was organised by the JRC's EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and the European Society of Toxicology In Vitro (ESTIV) and identified opportunities for exploiting recent advances in test methods and assessment approaches to move away from the two-year cancer bioassay in rodents.
The EU Agricultural Outlook, published on Monday 18 December, presents the EU's annual projections of agricultural commodity markets to 2030 and stresses the importance of environmental and climate change constraints.
Food of animal origin forms an essential part of our diet. Safe feed is a prerequisite for human and animal health and the productivity of the animal husbandry sector. High quality feed, including side stream products from food processing, is necessary for the production of high quality and safe food. Feed additives are key ingredients addressing these demands, but need to be authorised before being placed on the market.
A detailed inventory - compiled by JRC scientists - of 800 knowledge sources relevant to the Replacement, Reduction and Refinement (Three Rs) of animal procedures used for scientific purposes is now available online.
Since 2011, we at the Joint Research Centre (JRC) have been developing guidance on Best Environmental Management Practices for a number of priority sectors. These guides, developed with industry experts for a variety of sectors ranging from tourism to agriculture or car manufacturing, provide inspiration and guidance for organisations on a path to improve their environmental performance.
The JRC organised a dedicated workshop to bridge scientific communities involved in progressing the regulatory science of nanomedicines. There was a general agreement by the participants that existing standards and guidance documents might not be always sufficient for the regulation of nanomedicines due to their particularities.
JRC scientists have commemorated their late JRC colleague, Dr Jose-Manuel Zaldívar Comenges, by publishing a series of six papers on the Virtual Cell Based Assay a special issue of the journal Toxicology in Vitro.
Following the success of the 2014 and 2016 conferences on Big Data from Space held at the ESA in Frascati (Italy) and the Auditorio de Tenerife (Spain) respectively, the 2017 edition of the "Big Data from Space" Conference was again co-organised by the European Space Agency (ESA), the Joint Research Centre (JRC) of the European Commission, and the European Union Satellite Centre (SatCen).