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Science updates

Adapting the AOP concept to biomedical research Adapting the AOP concept to biomedical research
©EU, 2018
Jan 15 2018

JRC scientists have explored the application of Adverse Outcome Pathways (AOP) to improve mechanistic understanding of human disease pathophysiology in order to advance biomedical research and inform the development of new drugs.

The AOP concept was originally developed to facilitate better use of mechanistic understanding in determining the toxicological properties of chemicals. 

In particular, the goal has been to deliver reliable, animal-free methodologies for the hazard and risk assessment of chemicals, making greater use of in vitro and in silico methods.

Integration of data, application of new technologies and approaches, regulatory relevance and acceptance across sectors can warrant a better carcinogenicity safety assessment Integration of data, application of new technologies and approaches, regulatory relevance and acceptance across sectors can warrant a better carcinogenicity safety assessment
©EU, 2017
Jan 17 2018

The outcome of a workshop reviewing progress in carcinogenicity assessment of chemicals has been published in the latest issue of Toxicology in Vitro Special Issue. The workshop was organised by the JRC's EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and the European Society of Toxicology In Vitro (ESTIV) and identified opportunities for exploiting recent advances in test methods and assessment approaches to move away from the two-year cancer bioassay in rodents.

The EU Agricultural Outlook for the EU Agricultural Markets and Income 2017-2030
©EU
Dec 21 2017

The EU Agricultural Outlook, published on Monday 18 December, presents the EU's annual projections of agricultural commodity markets to 2030 and stresses the importance of environmental and climate change constraints.

High quality feed is necessary for the production of high quality and safe food High quality feed is necessary for the production of high quality and safe food
Dec 19 2017

Food of animal origin forms an essential part of our diet. Safe feed is a prerequisite for human and animal health and the productivity of the animal husbandry sector. High quality feed, including side stream products from food processing, is necessary for the production of high quality and safe food. Feed additives are key ingredients addressing these demands, but need to be authorised before being placed on the market.

Inventory of 3Rs Knowledge Sources Inventory of 3Rs Knowledge Sources
©EU, 2017
Dec 21 2017

A detailed inventory - compiled by JRC scientists - of 800 knowledge sources relevant to the Replacement, Reduction and Refinement (Three Rs) of animal procedures used for scientific purposes is now available online.

Dec 13 2017

Since 2011, we at the Joint Research Centre (JRC) have been developing guidance on Best Environmental Management Practices for a number of priority sectors. These guides, developed with industry experts for a variety of sectors ranging from tourism to agriculture or car manufacturing, provide inspiration and guidance for organisations on a path to improve their environmental performance.

'Bridging communities in the field of nanomedicine', JRC, Ispra, 27th-28th September 2017
©EU, 2017
Dec 11 2017

The JRC organised a dedicated workshop to bridge scientific communities involved in progressing the regulatory science of nanomedicines. There was a general agreement by the participants that existing standards and guidance documents might not be always sufficient for the regulation of nanomedicines due to their particularities.

Schematic representation of the fate processes within an in vitro test system Schematic representation of the fate processes within an in vitro test system
©EU, 2017
Dec 21 2017

JRC scientists have commemorated their late JRC colleague, Dr Jose-Manuel Zaldívar Comenges, by publishing a series of six papers on the Virtual Cell Based Assay a special issue of the journal Toxicology in Vitro.

Big Data from Space 2017 Conference image
Dec 04 2017

Following the success of the 2014 and 2016 conferences on Big Data from Space held at the ESA in Frascati (Italy) and the Auditorio de Tenerife (Spain) respectively, the 2017 edition of the "Big Data from Space" Conference was again co-organised by the European Space Agency (ESA), the Joint Research Centre (JRC) of the European Commission, and the European Union Satellite Centre (SatCen).

The joint meeting of PARERE and ESTAF, Ispra The joint meeting of PARERE and ESTAF, Ispra
©EU, 2017
Dec 07 2017

From the 27-29 November 2017, the annual meeting of EURL ECVAM's regulatory network (PARERE) and the joint meeting of PARERE and the ECVAM stakeholder forum (ESTAF) took place in Ispra.

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