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Science updates

in vitro colonies of cells grown after exposure to selected niosomes formulation (in blue: colonies formed by live cells)
©EU, 2017
Nov 21 2017

JRC scientists, in collaboration with six Italian Institutions, demonstrated that vesicular nanocarriers such as niosomes, are able to entrap drugs for safe delivery to targets to treat acute and chronic inflammation.

new certified reference material for nanoparticle size analysis new certified reference material for nanoparticle size analysis
©EU, 2017
Nov 17 2017

The Joint Research Centre (JRC) of the European Commission (EC) has developed a new Certified Reference Material (CRM) for nanoparticle size analysis. The CRM (ERM-FD101b) is a suspension of silica nanoparticles of nominally 85 nm in diameter in an aqueous solution and has been developed to support the implementation of the EC nanomaterial definition.

XPS analysis at the JRC Nanobiotechnology Laboratory XPS analysis at the JRC Nanobiotechnology Laboratory
©EU, 2017
Oct 26 2017

JRC scientists investigated the influence of various purification processes onto the surface composition and chemistry of gold nanoparticles. This work is relevant for the successful application of gold nanoparticles especially to be used as biomedicals and biosensing devices.

Disc-CLS measurements in the JRC's Engineering Materials Laboratory Disc-CLS measurements in the JRC's Engineering Materials Laboratory
©EU, 2017
Oct 24 2017

A collaborative study, organised by JRC, investigated the comparability and reliability of particle size values measured by a commercial centrifugal liquid sedimentation technique. The study was carried out to support the implementation of legislation related to nanomaterials.

The outcome of the study shows that particle size results are comparable when the method is calibrated with a well-characterised, good quality calibrant and that results can be achieved with an accuracy of about 10 %.

PTA measurements in the JRC's Engineering Materials Laboratory PTA measurements in the JRC's Engineering Materials Laboratory
©EU, 2017
Oct 20 2017

Scientists from the JRC and the Veterinary and Agrochemical Research Centre (CODA-CERVA, Belgium) have investigated the performance of a commercial particle tracking analysis device for size analysis of silica and polystyrene nano- and microparticles. The results of this study will help scientists in estimating the uncertainties of their measurement results in this field.

Samples used for the intercomparison on dry ice
©EU, 2017
Oct 12 2017

The JRC,  together with  scientists from Dutch, German and Danish organisations, organised an interlaboratory study to investigate the readiness of single-particle ICP-MS for the determination of the median diameter of silver nanoparticles in food. The study revealed that significant improvements are needed before the method can be reliably used for official control purposes.

Identification of regulatory needs for nanomedicines Identification of regulatory needs for nanomedicines
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Sep 25 2017

Europe received fewer submissions of nanomedicines for market authorisation in comparison to other regions in the world in the last five years.

This is one of the major outcomes of a recent survey performed with international regulatory bodies done by JRC scientists in collaboration with the Norwegian SINTEF Institute for Materials and Chemistry.

Engineering effective antimicrobial agents
©zuki70-Fotolia.com
Sep 11 2017

The JRC – in collaboration with other Research Institutions – identified and measured a new mechanism of antimicrobial activity.

They predicted, engineered and demonstrated antimicrobial monolayer poration. The visualisation in live bacteria demonstrated that bacterial cell death can happen within minutes. 

Membrane poration is fundamental to cell function. In particular, the spread of antimicrobial resistance re-emphasises poration as a means of fighting infections.

Silica nanoparticles
©EU, 2017
Jul 24 2017

JRC scientists demonstrated the effect of silica nanoparticle agglomeration on the level and mechanism of their uptake by cells, i.e. agglomerated particles accumulated more in cells than non-agglomerated ones and presented a modified mechanism of cellular internalisation.

Silica nanoparticles (NPs) are increasingly present in variety of consumer products including cosmetics and food supplements.

They are in development for diverse medical applications such as drug delivery systems, tissue engineering and biosensors.

Nanobiotechnology laboratory
©EU,2017
Jul 07 2017

JRC scientists – in collaboration with research groups from the Swiss Federal Laboratories for Materials Science and Technology EMPA and the French Alternative Energies and Atomic Energy Commission CEA -  suggest methods for nanoparticle aggregate recognition that might become highly relevant for industry when fulfilling legal requirements for nanomaterials according to EU legislation.

This includes the registration in line with the chemicals legislation (REACH) or the labelling of cosmetic products or food. 

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