EU Science Hub

Science updates

Chemical mixtures – EU research consortia take stock of the science-policy landscape
Oct 15 2018

The JRC has worked with five EU funded research consortia, EC department for Research and Innovation, the European Environment Agency and the European Food Safety Authority to produce a paper which identifies research and policy needs to deal with the assessment and management of potential risks posed by chemical mixtures to human health and the environment.

Oct 01 2018

The JRC's EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) has launched a second call for tender to review alternative methods and models being used for research in the areas of Cardiovascular diseases, Breast Cancer, Immunogenicity testing for advanced therapy medicinal products, Autoimmune diseases an

Sep 28 2018

JRC scientists collected and analysed mechanistic information on the effects of chemicals on eight organs identified as relevant for acute systemic toxicity in humans. The ultimate aim is the replacement of the use of animals in the regulatory assessment of acute oral toxicity.

This knowledge is expected to support the development and application of adverse outcome pathways (AOPs) and mechanistically relevant new approach assessment methodologies.

Pulmonary edema
Sep 25 2018

JRC scientists contributed to a review of the state-of-the-science on available mechanisms and assays to assess acute inhalation toxicity with a focus on non-animal testing approaches.

Scientists from the JRC's EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) joined a working group, together with other international experts, to assess acute inhalation toxicity.  They discussed how existing knowledge can be used to design effective non-animal testing approaches.

How to use in vitro determined hepatic clearance to predict BCF values
Sep 19 2018

JRC scientists have contributed to two new OECD Test Guidelines that describe how to measure in vitro fish hepatic clearance. This information is key for making more reliable predictions of bioconcentration of chemicals in fish when combined with mathematical models.

Intrinsic clearance relates to the rate at which the liver can break down a chemical which has been taken up by a fish from its surroundings.

Good In Vitro Method Practices (GIVIMP)
©EU, 2018
Sep 17 2018

The Organisation for Economic Cooperation and Development (OECD) has published guidance on Good In Vitro Method Practices (GIVIMP) to ensure the reliability and integrity of in vitro data used for the safety assessment of chemicals.

Human iPSC-derived neuronal cells (stained for β-III-Tubulin) after 21 days of differentiation
Jul 27 2018

JRC scientists – in close collaboration with experts from international organisations - develop, evaluate and promote non-animal testing strategies based on in vitro methods to improve the regulatory assessment of chemicals which may cause developmental neurotoxicity (DNT) effects.

Currently there is only very limited information on potential developmental neurotoxicity (DNT) effects of the many thousands of chemicals that we come into contact with in our daily lives.

Calls for tender seek experts for training tools on alternatives to animal testing
Jun 26 2018

The European Commission has recently launched open calls for tender inviting experts to develop eLearning tools to facilitate uptake of non-animal alternative approaches in science.

The JRC's European Union Reference Laboratory for the Validation of Alternative Methods (EURL ECVAM) is collaborating closely with Directorate General Environment who is leading the initiative.

Members of the new ESAC pictured with JRC colleagues and invited observers from Brazil and Korea
May 31 2018

New ESAC will meet in December to review affinity reagents produced using animal-free technologies and methods for skin sensitisation.

The JRC's EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) is delighted to announce the renewal of the EURL ECVAM Scientific Advisory Committee (ESAC) whose members were formally appointed on the 16th of April 2018.

Survey on issues influencing end-user confidence in complex in vitro models
May 22 2018

The JRC's European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) is conducting a survey to collect scientific opinion on how to assess the relevance and fitness-for-purpose of complex in vitro models such as organ-on-chip devices to understand how to best facilitate their uptake and application in a variety of areas including biomedical research for drug development and toxicological testing for safety assessment.


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