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Science updates

Non-animal alternatives for acute systemic toxicity testing Non-animal alternatives for acute systemic toxicity testing
©EU, 2017
Aug 04 2017

The JRC participated along with other international experts in the review of current approaches for acute systemic toxicity testing.

To facilitate the use of alternative methods and their regulatory acceptance it is important to keep the momentum for data curation and sharing, education and training for users and regulators, and international harmonisation of testing requirements.   

Male thyroid anatomy Male thyroid anatomy
©Fotolia,Cliparea.com
Jul 04 2017

The JRC's EURL ECVAM has launched a validation study to assess in vitro methods for the detection of chemicals which disrupt thyroid function.

There is global concern about substances, natural and man-made, which have the potential to interfere with the endocrine system.

The thyroid’s main role in the endocrine system is to regulate metabolism through the action of thyroid hormone, by extracting iodine from the blood and incorporating it into thyroid hormones.

hiPSC neurons and glia hiPSC neurons and glia
©EU, 2017
Jun 26 2017

JRC scientists have published a written protocol, accompanied by a video demonstration for the differentiation of human pluripotent stem cells into neurons and glia.

This new tool should increase reproducibility in laboratory procedures through visual learning.

The Journal of Visualized Experiments (JoVE) has responded to a universally experienced problem within the world of biomedical science to reproduce the results of other labs (today only 10-30% of published scientific articles can be successfully reproduced).

3D human cell microscope background
©Ivanc7 - Fotolia.com
Jun 12 2017

JRC scientists have shown human induced pluripotent stem cell (hiPSC) to be a promising in vitro model for neurotoxicity testing. These stem cell-based systems offer an innovative human-relevant alternative to traditional animal tests that can improve the efficacy of drug discovery and support safety assessment.

Reduction of animal tests for the quality control of veterinary vaccines: VICH releases two new guidelines Reduction of animal tests for the quality control of veterinary vaccines: VICH releases two new guidelines
©EU, 2017
May 31 2017

JRC scientists supported the development of two guidelines released by the International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products (VICH) on the harmonisation of criteria to waive target animal batch safety tests for inactivated and live veterinary vaccines. Their implementation (from May 2018 onwards) is a major step towards international harmonisation and will reduce the number of animals used for batch release testing.

JRC Summer School on Alternative Approaches for Risk Assessment JRC Summer School on Alternative Approaches for Risk Assessment
©EU, 2017
May 23 2017

From 16 to 19 May, the JRC hosted in Ispra (Italy) 101 postgraduate students and early-career scientists from 29 countries worldwide for the JRC Summer School on Alternative Approaches for Risk Assessment.

Reducing animal testing while improving the safety assessment of chemicals for skin allergies Reducing animal testing while improving the safety assessment of chemicals for skin allergies
©taborsky - Fotolia.com
May 03 2017

The JRC's European Union Reference Laboratory for alternatives to animal testing (EURL ECVAM) has published its recommendation on the use of non-animal approaches for skin sensitisation (allergy) testing.

JRC strengthen its collaboration with the European Food Safety Authority JRC strengthen its collaboration with the European Food Safety Authority
©EU, 2017
Apr 10 2017

On 5th April JRC-Ispra hosted a delegation from EFSA to discuss specific topics of common interest in the area of risk assessment related to chemicals.

A workshop was organised to discuss ongoing joint projects and explore topics of common interest to pave the road for further collaboration. It involved 19 experts from EFSA and several colleagues from the JRC Directorates D and F. Different subjects were on the agenda spanning from endocrine disruptors to environmental modelling and risk assessment.

Understanding nanomaterial toxicity by leveraging mechanistic information on chemicals Understanding nanomaterial toxicity by leveraging mechanistic information on chemicals
©EU, 2017
Apr 04 2017

JRC scientists carried out a study illustrating how the mechanisms of nanomaterial toxicity can be better understood by exploiting the broader body of mechanistic information on chemicals in general.

The pathway from liver injury to liver fibrosis The pathway from liver injury to liver fibrosis
©EU, 2017
Apr 04 2017

JRC scientists have used an Adverse Outcome Pathway approach to explain how some chemicals can potentially cause liver fibrosis in humans in order to support the development of non-animal approaches to chemical safety assessment.

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