EU Science Hub

Science updates

Members of the new ESAC pictured with JRC colleagues and invited observers from Brazil and Korea
©EU, 2017
May 31 2018

New ESAC will meet in December to review affinity reagents produced using animal-free technologies and methods for skin sensitisation.

The JRC's EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) is delighted to announce the renewal of the EURL ECVAM Scientific Advisory Committee (ESAC) whose members were formally appointed on the 16th of April 2018.

Survey on issues influencing end-user confidence in complex in vitro models
©Wikipedia Commons
May 22 2018

The JRC's European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) is conducting a survey to collect scientific opinion on how to assess the relevance and fitness-for-purpose of complex in vitro models such as organ-on-chip devices to understand how to best facilitate their uptake and application in a variety of areas including biomedical research for drug development and toxicological testing for safety assessment.

ELISA – Enzyme-linked immunosorbent assay to measure antibodies or antigen
©European Union 2018
May 03 2018

New report summarises the outcome of a workshop organised by the Joint Research Centre's EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) and VAC2VAC* partners on the design of multi-centre validation studies.

Reviewing the use of alternative methods in biomedical research
©hakat –
Apr 18 2018

The JRC's EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) has launched a study to review alternative methods and models being used for research in the areas of Respiratory Tract Diseases and Neurodegenerative Disorders.

3Rs education and training
Feb 27 2018

The JRC has launched a study to review available education and training resources that support the 3Rs approach: Replacement, Reduction and Refinement of animal procedures used for scientific purposes.

JRC's ChemAgora web portal simplifies access to chemical data
©EU, 2018
Feb 09 2018

The JRC's ChemAgora web portal provides search capabilities to retrieve chemical data from a plethora of online resources enabling users to access both regulatory information on chemicals and public databases on chemical properties.

ChemAgora is intended to support chemical risk assessment activities by assisting stakeholders to gain a quick overview of globally available data about chemicals they are interested in. This speeds up the process of data discovery and saves valuable resources.

Assessing safety of nanomaterials with less animal testing
©EU, 2018
Feb 02 2018

The JRC participated in an expert group of regulators, academics and industry to discuss the way forward in nanotoxicology, concluding that there is a strong potential for use of alternative methods that will impact the reduction, refinement and replacement (3Rs) of animal testing.

Integration of data, application of new technologies and approaches, regulatory relevance and acceptance across sectors can warrant a better carcinogenicity safety assessment
©EU, 2017
Jan 17 2018

The outcome of a workshop reviewing progress in carcinogenicity assessment of chemicals has been published in the latest issue of Toxicology in Vitro Special Issue. The workshop was organised by the JRC's EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and the European Society of Toxicology In Vitro (ESTIV) and identified opportunities for exploiting recent advances in test methods and assessment approaches to move away from the two-year cancer bioassay in rodents.

Adapting the AOP concept to biomedical research
©EU, 2018
Jan 15 2018

JRC scientists have explored the application of Adverse Outcome Pathways (AOP) to improve mechanistic understanding of human disease pathophysiology in order to advance biomedical research and inform the development of new drugs.

The AOP concept was originally developed to facilitate better use of mechanistic understanding in determining the toxicological properties of chemicals. 

In particular, the goal has been to deliver reliable, animal-free methodologies for the hazard and risk assessment of chemicals, making greater use of in vitro and in silico methods.

Schematic representation of the fate processes within an in vitro test system
©EU, 2017
Dec 21 2017

JRC scientists have commemorated their late JRC colleague, Dr Jose-Manuel Zaldívar Comenges, by publishing a series of six papers on the Virtual Cell Based Assay a special issue of the journal Toxicology in Vitro.