EU Science Hub

Science updates

A new freely available knowledge base of non-animal models used in the immune-oncology field is now online
Sep 20 2021

The JRC adds a new knowledge base of 542 models used in the immuno-oncology field to its freely available collection of advanced non-animal models for biomedical research.

In 2020 approximately 2.7 million new cancer cases were diagnosed in the EU-27, representing an enormous  burden on individuals, healthcare systems and society in general.

The JRC has published an independent scientific peer review of two Genomic Allergen Rapid Detection (GARD) test methods for the assessment of chemicals inducing skin allergies
Jul 23 2021

The JRC has published an independent scientific peer review of two Genomic Allergen Rapid Detection (GARD) test methods for the assessment of chemicals inducing skin allergies. 

COVID-19: Finding a way to put the puzzle together
Jun 24 2021

The COVID-19 pandemic is engaging a great number of scientists worldwide and published knowledge is increasing at an exponential rate. The JRC’s CIAO project gives the scientific community a reliable map to navigate through the COVID-19 knowledge ocean. Why not join the effort! 

COVID-19 is a complex disease. Scientists across the globe are working hard to understand the biological mechanisms underpinning its sometimes devastating effects. However, keeping up with the tens of thousands of scientific publications related to COVID-19 is a formidable challenge. 

New OECD guideline on Defined Approaches for skin sensitisation
Jun 23 2021

The JRC’s EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) contributed to the new OECD guideline on Defined Approaches for skin sensitisation. This can replace the need for animal testing and represents the first example of international standards for chemical safety assessment based on the integration of non-animal data.

One important obstacle to progress in the field of neurodegenerative diseases is the heavy reliance on animal models which are failing to capture key features of human biology and disease
Apr 28 2021

To mark Parkinson’s awareness month, the JRC has published a freely available knowledge base of non-animal models to advance research into neurodegenerative diseases such as Parkinson’s and Alzheimer’s.

Dementia affects over 8 million people in Europe and this figure is expected to double in 30 years. It is estimated that up to 10 million people suffer from Parkinson’s worldwide.

OECD Guidance document on the characterisation, validation and reporting Physiologically Based Kinetic models for regulatory purposes
Apr 13 2021

JRC researchers have led the development of international guidance to support the use of physiologically based kinetic models in chemical risk assessment. The guidance document has been adopted and published by the Organisation for Economic Co-operation and Development (OECD).

The JRC presented the findings of the recently completed Fitness Check of the EU legal framework on endocrine disruptors
Mar 30 2021

During the European Commission’s Second Annual Forum on Endocrine Disruptors, the JRC presented the findings of the recently completed Fitness Check of the EU legal framework on these chemicals.

Endocrine disruptors (EDs) are chemical substances that cause adverse effects by interfering with the hormonal (endocrine) system. 

Moving away from animal use in science: why and how to introduce the Three Rs into secondary schools, universities and continuing education programmes
Mar 08 2021

In a recent report, the JRC makes the case for introducing teaching on the Three Rs - Replacement, Reduction and Refinement of animal experiments - into secondary schools, universities and continuing education programmes.

Raising awareness of the Three Rs among teachers and students is fundamental to accelerate the reduction and replacement of animal testing and to advance the uptake of alternative approaches in life science research.

Repeated exposure to persistent organic pollutants might affect neurodevelopmental processes critical for human brain development
Feb 23 2021

Repeated exposure to persistent organic pollutants might affect neurodevelopmental processes critical for human brain development, as shown in a human in vitro neuronal model. This could contribute to learning and memory impairment in children.

Halogenated persistent organic pollutants (POPs) are toxic chemicals that are persistent in the environment.

They were or are still currently used as components of pharmaceuticals, industrial chemicals, solvents or pesticides.

A JRC report describes recent highlights to show the value of IPCHEM in understanding chemical exposure to achieve key objectives of the Chemicals Strategy for Sustainability
Jan 11 2021

IPCHEM provides a wealth of occurrence data on chemicals present in our environment, food, indoor air, and even in our bodies. A JRC report describes recent highlights to show the value of IPCHEM in understanding chemical exposure to achieve key objectives of the Chemicals Strategy for Sustainability.

Chemicals are everywhere and are essential to our modern way of life. In addition to enjoying their benefits however, any potential risks to human health and the environment have to be anticipated and properly managed. And for this we need to know what chemicals end up where.

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