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Science updates

Adverse Outcome Pathway on Inhibition of the mitochondrial complex I of nigro-striatal neurons leading to parkinsonian motor deficits
Adverse Outcome Pathway on Inhibition of the mitochondrial complex I of nigro-striatal neurons leading to parkinsonian motor deficits
Apr 12 2019

JRC scientists have been collaborating with EFSA experts on the development of an Adverse Outcome Pathway to establish the biological plausibility of an association between exposure to pesticides and Parkinson's disease.

Special issue of Toxicology and Applied Pharmacology
Special issue of Toxicology and Applied Pharmacology
Feb 06 2019

JRC scientists have co-edited and contributed to a special issue of Toxicology and Applied Pharmacology proposing how alternative methods to animal testing can be used to assess chemicals for their potential to disrupt brain development in children

Next Generation Risk Assessment of Cosmetics
Jan 22 2019

In an international collaboration of regulators and industry, JRC scientists contributed to the compilation of overarching principles for the safety assessment of cosmetics without animal testing.

Computational methods for nanomaterials
Computational methods for nanomaterials
Dec 18 2018

JRC scientists have published a series of papers assessing the availability and applicability of computational models in the safety assessment of nanomaterials, with a view to promoting their further development and use in regulatory decision making.

A Tale of Two Toxicologies – new book on the history of alternative methods
A Tale of Two Toxicologies – new book on the history of alternative methods
Dec 11 2018

JRC scientists have contributed to the editing and writing of a book on the history of alternative methods in toxicology and chemical safety assessment.

The book presents historical perspectives on the development, validation, acceptance and use of alternatives to animal testing over the past half-century, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement of animal procedures).

Pooling resources to promote the use of alternative methods at the annual conference of the European Partnership for Alternative Approaches to Animal Testing (EPAA)
Dec 05 2018

The annual conference of the European Partnership for Alternative Approaches to Animal Testing (EPAA) took place on 20 November 2018 in Brussels. The event showcased recent EPAA achievements and included an expert panel session, with the participation of the JRC, that discussed how new types of safety data derived from alternative methods can be exploited in regulatory decision making.

Computer code
Nov 22 2018

JRC scientists are part of an international initiative developing principles and protocols for the consistent use of computational models in chemical safety assessment to promote greater acceptance in regulatory applications.

The In Silico Toxicology (IST) Protocol initiative is focusing on how results from computational methods should be generated, interpreted, assessed and documented with a view to increasing confidence in their use.

Novel in vitro tools for the assessment of neurotoxicity induced by nanoparticles
Nov 19 2018

JRC contributed to research carried out by Italian research organisations in Pavia and Milan. This work demonstrated that new 3D in vitro cell based models can be applied to assess the neurotoxicity of magnetite nanoparticles. 3D  cultures may represent good "near-to-in-vivo" models leading to better interpretation of toxicological effects to humans.

JRC's EURL ECVAM representatives promote JRC activities on alternative methods at the 20th international congress on in vitro toxicology (ESTIV 2018)
JRC's EURL ECVAM representatives promote JRC activities on alternative methods at the 20th international congress on in vitro toxicology (ESTIV 2018)
Nov 08 2018

Highlights of the JRC work presented include using Adverse Outcome Pathways to guide in vitro method development, the recently published OECD guidance on good in vitro method practices, results of an international survey on validating complex in vitro models, and an update of the JRC validation study of in vitro methods for identifying thyroid disrupters.

Zebrafish (Danio rerio)
Nov 07 2018

JRC scientists have contributed to the revision of OECD Guidance Document 23 "Aqueous-Phase Aquatic Toxicity Testing of Difficult Test Chemicals" that addresses good practices to be applied in aquatic toxicity testing.

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