We are doing science for policy
The Joint Research Centre (JRC) is the European Commission's science and knowledge service which employs scientists to carry out research in order to provide independent scientific advice and support to EU policy.
JRC scientists - in close collaboration with international organisations – revised the first guidance on Good Cell Culture Practice (GCCP) by expanding it to aspects of quality assurance for in vitro cell culture focusing on the increasingly diverse cell types and culture formats used in research and elsewhere.
The first guidance on GCCP, coordinated by the JRC in 2005, identified a set of core principles of best practice for working with cell and tissue culture systems. As a result of a workshop organised in 2015 by the Center for Alternatives to Animal Testing at the US John Hopkins University, scientists of the JRC and other European, Japanese and North American organisations summarised the more recent developments in cell and tissue cultures, and in particular addressed the new technological developments of human pluripotent stem cell lines and stem-cell derived models.
Stem cells and their derivatives represent relevant in vitro toxicity models as they are characterised by unlimited self-renewal and the capacity to differentiate into several human tissue-specific somatic cells such as liver cells, hart and brain cells. The publication aims to stimulate the development and implementation of quality standards and best scientific practices for stem cell-based culture models in research, development and regulatory applications.
Read more in:
D. Pamies et al.: "Good Cell culture Practice for stem cells and stem-cell-derived models", ALTEX 34 (2017) 95-132, doi: 10.14573/altex.1607121