NanoBiotechnology laboratory

NanoBiotechnology laboratory

The JRC has up-to-date equipped laboratories to investigate nanomaterials safety as well as the detection, identification and characterisation of nanomaterials in food and consumer products. Its work focuses on a science-based understanding of nanomaterial properties and effects.

Major topics of research include:

  • Synthesis of nanoparticles including radiolabelled nanoparticles, in particular TiO2, ZnO, CeO2, FexOy, SiO2, Ag, Au and carbon based nanomaterials;
  • Physico-chemical characterisation of nanomaterials;
  • Detection, identification and quantification of nanomaterials in complex matrices (such as blood, serum, food, cosmetic products);
  • Interaction of nanomaterials with biological systems (proteins, enzymes, cell membranes);
  • Development and optimization of in vitro test methods for the assessment of nanomaterials-induced toxicity;
  • Study of bio-kinetics and cellular uptake of nanomaterials (including radiolabelled nanoparticles);
  • Investigation of translocation of nanomaterials (including radiolabelled nanoparticles) across physiological barriers using in vitro models;
  • Mechanistic nanotoxicology studies using large-scale screening tools including transcriptomics, metabonomics, proteomics and high-content image analysis;
  • Development of bio-functional surfaces: surface functionalisation and controlled immobilization of proteins for optimized cell culture and molecular detection.

 

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Read: JRC NanoBiotechnology Laboratory.pdf file [250 KB]