The JRC has up-to-date equipped laboratories to investigate nanomaterials safety as well as the detection, identification and characterisation of nanomaterials in food and consumer products. Its work focuses on a science-based understanding of nanomaterial properties and effects.
Major topics of research include:
- Synthesis of nanoparticles including radiolabelled nanoparticles, in particular TiO2, ZnO, CeO2, FexOy, SiO2, Ag, Au and carbon based nanomaterials;
- Physico-chemical characterisation of nanomaterials;
- Detection, identification and quantification of nanomaterials in complex matrices (such as blood, serum, food, cosmetic products);
- Interaction of nanomaterials with biological systems (proteins, enzymes, cell membranes);
- Development and optimization of in vitro test methods for the assessment of nanomaterials-induced toxicity;
- Study of bio-kinetics and cellular uptake of nanomaterials (including radiolabelled nanoparticles);
- Investigation of translocation of nanomaterials (including radiolabelled nanoparticles) across physiological barriers using in vitro models;
- Mechanistic nanotoxicology studies using large-scale screening tools including transcriptomics, metabonomics, proteomics and high-content image analysis;
- Development of bio-functional surfaces: surface functionalisation and controlled immobilization of proteins for optimized cell culture and molecular detection.
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JRC NanoBiotechnology Laboratory.pdf