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The Joint Research Centre (JRC), as the European Commission’s in-house science service, has a has a longstanding experience on health-related activities. These range from the detection of potentially hazardous substances in food, to the monitoring of health threats and environmental risks, as well as standardisation of measurements and validation of methods for safety assessment. The JRC is also now successfully developing new expertise in important public health-related areas, such as cancer and rare diseases, nutrition and healthy ageing, as well as behavioural sciences applied to public health.