Validation of methods for the detection and quantification of engineered nanoparticles in food

Abstract: 

The potential impact of nanomaterials on the environment and on human health has already triggered legislation requiring labelling of products containing nanoparticles. However, so far, no validated analytical methods for the implementation of this legislation exist. This paper outlines a generic approach for the validation of methods for detection and quantification of nanoparticles in food samples. It proposes validation of identity, selectivity, precision, working range, limit of detection and robustness, bearing in mind that each ``result?? must include information about the chemical identity, particle size and mass or particle number concentration. This has an impact on testing for selectivity and trueness, which also must take these aspects into consideration. Selectivity must not only be tested against matrix constituents and other nanoparticles, but it shall also be tested whether the methods apply equally well to particles of different suppliers. In trueness testing, information whether the particle size distribution has changed during analysis is required. Results are largely expected to follow normal distributions due to the expected high number of particles. An approach of estimating measurement uncertainties from the validation data is given.

Authors
Authors: 
DEHALU Vincent, GROMBE Ringo, ROEBBEN Gert, CHAUDHRY Quasim, LOESCHNER Katrin, LARSEN Erik H., RAMSCH R., LEGROS Samuel, VON DER KAMMER Frank, LINSINGER Thomas, DELAHAUT Philippe, DUDKIEWICZ Agnieszka, PETERS Ruud, TIEDE Karen, WEIGEL Stefan
Publication Year
Publication Year: 
2013
Type

Type:

Appears in Collections
Appears in Collections: 
Institute for Reference Materials and Measurements
Science Areas
JRC Institutes
Publisher
Publisher: 
ELSEVIER SCI LTD
ISSN
ISSN: 
0308-8146
Citation
Citation: 
FOOD CHEMISTRY p. 1959-1966 no. 2-3 vol. 138