Since their inception in pharmaceutical applications, physiologically-based kinetic (PBK) models are increasingly
being used across a range of sectors, such as safety assessment of cosmetics, food additives, consumer goods,
pesticides and other chemicals. Such models can be used to construct organ-level concentration-time profiles of
xenobiotics. These models are essential in determining the overall internal exposure to a chemical and hence its
ability to elicit a biological response. There are a multitude of in silico resources available to assist in the
construction and evaluation of PBK models. An overview of these resources is presented herein, encompassing all
attributes required for PBK modelling. These include predictive tools and databases for physico-chemical properties
and absorption, distribution, metabolism and elimination (ADME) related properties. Data sources for existing PBK
models, bespoke PBK software and generic software that can assist in model development are also identified.
On-going efforts to harmonise approaches to PBK model construction, evaluation and reporting that would help
increase the uptake and acceptance of these models are also discussed.