The Open Innovation concept has pervaded the academic and policy debate, due to its potential to further stimulate the circulation of knowledge across business partners and institutions and, consequently, to increase their innovation potential. The contribution of this paper is to unveil the economic returns associated to such a model, to answer the main question whether the productivity growth slowdown observed in the EU in recent years could be overcome through a more open and dynamic innovation environment. An empirical analysis conducted on sectoral data for 16 EU countries is provided, exploiting three waves of the Community Innovation Survey. Results confirm the role of Open Innovation in stimulating – even at the aggregate level – innovation, and, to a limited extent, to economic returns. However, when testing for the association between Open Innovation and economic growth, no robust effect emerges.