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EURL ECVAM Recommendation on the use of non-animal approaches for skin sensitisation testing

Considerable progress has been made in non-animal methods and approaches for skin sensitisation assessment since the publication in 2013 of the EURL ECVAM strategy for this endpoint. This report illustrates EURL ECVAM views on the regulatory use of individual test methods, including two in vitro methods peer reviewed by ESAC, the LuSens and the U-SENS™ and on defined approaches and provides EURL ECVAM recommendations on future work to be undertaken in the area.