The Digital Agenda Toolbox provides support to regional and national authorities to develop a thorough understanding of the digital growth potential stemming from the Digital Agenda for Europe (DAE). It highlights the opportunities Information and Communication Technology (ICT) entails as a key element in their national or regional research and innovation strategies for smart specialisation (RIS3) and related Operational Programmes (OPs). At the same time, this Toolbox provides guidance for the fulfilment of the DAE-related ex-ante conditionalities that will form the basis for using European Regional Development Funds (ERDF) for ICT investments. It thus complements the RIS3 Guide and other related policy documents such as the Guide on Broadband Investment. The Toolbox furthermore provides hands-on assistance for developing a strategic policy framework for digital growth by discussing the dos and don'ts of the process and giving examples of good practises.