Current and emerging in vitro methods for genotoxicity and carcinogenicity

Abstract: 

The evaluation of genotoxicity and carcinogenicity is an essential prerequisite for the assessment of pharmaceuticals, industrial chemicals and consumer products potential hazard and for their marketing authorization. A number of well-established in vitro and in vivo testing methods are available and able to predict genotoxic and carcinogenic potential, yet research is on-going and is aimed at the development of a new generation of in vitro tests to enhance their predictivity and performance and to reduce the number of animals. In this context, the following Chapter is meant to review the existing in vitro testing methods and update on the emerging in vitro approaches for the assessment of genotoxicity and carcinogenicity.

Authors
Authors: 
PHRAKONKHAM Pascal, MADIA Federica, CORVI Raffaella
Publication Year
Publication Year: 
2014
Type

Type:

Appears in Collections
Appears in Collections: 
Institute for Health and Consumer Protection
Science Areas
JRC Institutes
Publisher
Publisher: 
Humana Press Springer Science + Business Media, LLC
ISBN
ISBN: 
978-1-4939-0520-1
ISSN
ISSN: 
1557-2153
URI
URI : 
Citation
Citation: 
In vitro Toxicology Systems p. 307-332