Klaus Lützenkirchen studied chemistry at the University of Mainz and at the University of California, Irvine, with specialisation in nuclear chemistry.
He holds a PhD on fusion reactions of heavy ions from the University of Mainz, Germany. His post-doctoral research was on the search for "strange matter" at the heavy-ion research facility of GSI Darmstadt, Germany, and at the Weizmann Institute, Rehovot, Israel. He then worked on chemical properties of metal clusters stored in ion traps and obtained his Habilitation from the University of Mainz. In 1997 he was appointed as Professor of nuclear chemistry at the University of Strasbourg, France, with R&D focused on chemical properties of actinide elements.
Since 2002, he has worked at the Joint Research Centre and is presently Head of the Nuclear Safeguards and Forensics Unit at ITU, Karlsruhe. His activities are focused on nuclear forensics, nuclear safeguards and non-proliferation.