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The Joint Research Centre (JRC) is the European Commission's science and knowledge service which employs scientists to carry out research in order to provide independent scientific advice and support to EU policy.
Converging evidence shows that viruses such as SARS-CoV-2 and influenza are mainly transmitted through the air. Merging the two non-contact transmission modes, large-droplet and aerosol, into a unique non-contact airborne transmission mode, is essential to break the chain of infection, according to a new JRC study.
When you breathe, speak, laugh, cough, sneeze or sing you produce droplets, small and bigger ones. If these respiratory droplets are generated by an infectious individual, they may contain viruses.
Respiratory viruses, such as SARS-CoV-2 or influenza, have traditionally been associated with three modes of transmission:
JRC scientists call into question the demarcation between droplet and airborne transmission. In previous work dated back as early as 2008 and more recently in April 2020 and May 2021, they have been calling for a revision of the guidelines on the modes of transmission of respiratory viruses.
In a new study published in May, they propose to merge the two non-contact transmission modes, large-droplet and aerosol, into a unique non-contact airborne transmission mode.
The airborne route is a potentially important transmission pathway for SARS-CoV-2 or influenza in indoor environments.
However, scientists in the medical community have been emphasising that large droplets are mainly responsible for respiratory virus transmission, indicating that aerosol transmission is much less important. This position seems to have finally changed a couple weeks ago with the updates related to SARS-CoV-2 in the USA, Centers for Disease Control and Prevention (May 7, 2021), and the WHO (April 30, 2021).
The main argument for the reluctance to accept airborne transmission as a major pathogen transmission mode is that when one takes an air sample to isolate the virus to cultivate it experimentally, they fail to cultivate it. To them, this means that the virus is inactivated.
But, according to JRC scientist Nikolaos Stilianakis, “there are many reasons to justify this inactivation of the virus, but this does not mean that viable virus is not present in the airborne droplets.”
He says: “The until recently prevailing view that large droplets are mainly responsible for virus transmission rather than fine airborne droplets is based on knowledge of the early 1900s and misconceptions. It is encouraging to see the very recent update of the USA CDC and WHO recommendations finally pointing in the right direction”.
This new definition of a unique non-contact airborne transmission mode has significant repercussions on public health interventions to break the chain of infection, specifically regarding
JRC scientists have been exploring for years the transmission modes of respiratory viruses and their relative importance. The emergence of SARS-CoV-2 and the role of aerosols in the transmission of the virus brought JRC previous and current work in the centre of the debate.
In the face of newly emerging respiratory infections, understanding how the virus spreads is key for breaking the chain of infection.
JRC scientists urge for closer collaboration between aerosol scientists, epidemiologists, experimentalists and clinicians to resolve several open questions about virus-transmission pathways.