EURL ECVAM hosts first meeting of European 3Rs Centres (21-22 April 2015)
Female liver cells, and in particular those in menopaused women, are more susceptible to adverse effects of drugs than their male counterparts, according to new research carried out by the JRC.
The results of an inter-laboratory comparison study on a method for assessing the cytotoxicity of nanomaterials have been published. This is an important step towards a harmonised method for toxicity screening of nanomaterials.
This video presents the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and explains the validation process of alternative methods.
The JRC has validated and recommended a new method which is not based on animal testing, to identify chemicals that can trigger skin allergies, estimated to affect already 20% of the population in Europe.
Today's adoption by the OECD of two new test guidelines will contribute to reducing the number of animals currently used worldwide to identify chemicals with the potential to trigger skin allergies. The new JRC recommended test methods will support the identification of chemicals that can lead to allergic contact dermatitis (ACD), one of the most common occupational diseases. Skin allergies are a growing health problem and are estimated to affect already 20% of the population in Europe.
The JRC has released a new strategy on how to replace, reduce and refine the use of fish in testing of chemicals’ effect on flora and fauna in water (aquatic toxicity) and chemicals’ uptake and concentration in living organisms (bioaccumulation). Out of the 11.5 million animals used for experimental purposes in the EU (2011 data), cold blooded animals, namely reptiles, amphibians and fish represent 12.4%. In the case of specific testing for toxicological safety assessment, fish represent 18% of the one million animals used.
The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) of the European Commission's Joint Research Centre has just released a strategy on how to reduce, refine and ultimately avoid the use of animals for acute mammalian systemic toxicity testing. The strategic aims and associated objectives identified are intended to progress the field on multiple fronts and to provide a framework for prioritisation of alternative methods submitted for validation.
The report "Assessment of Mixtures – Review of Regulatory requirements and Guidance" provides an up to date overview of EU regulations and risk assessment regimes and requirements regarding potential mixtures effects.