EU Science Hub


How much of the material do I need?

The amount of material needed depends on the analytical method used.

But it should be always at least the minimum sample intake stated on the certificate (otherwise the homogeneity is not guaranteed).

How reliable is my measurement result?

The reliability of the method applied has to be demonstrated by means such a

s method validation, proper use of quality assurance tools (including the use of CRMs) and the participation in proficiency testing.

How should I choose input distributions for the model inputs?

Sensitivity analysis is not concerned with the choice of the distributions f

ollowed by the model inputs. These distributions have to be derived from available sources of information, such as expert opinions or literature. Results of the sensitivity analysis exercise are conditional upon the distributions chosen.

More information: Sensitivity analysis

How should I correct for moisture and water content?

The method for water and moisture correction specified on the certificate mu

st be followed, because different methods may give different results. Naturally, the moisture content is determined on a separate subsample than the one used for analysis.

How should I use the data obtained on measurements of a CRM?

There are different possibilities to use the data obtained on a measurement

of a CRM. It can be used to help to:

  • validate a method of measurement. This is to see, if the observed value and the certified value match within the uncertainty.
  • verify a specific measurement procedure. This is to see, if the observed value and the certified value match within the uncertainty under the specific laboratory conditions.
  • control the accuracy of measurements within the uncertainty.
  • calibrate a measurement device for a specific type of measurement. This is to establish the relation between a ‘signal’ and the quantity intended to be measured (usually a concentration). In the simple case, a calibration factor and its uncertainty is calculated from the observed value and the certified value.
  • establish proficiency testing. The use of a well characterised (i.e. certified) material in form of a ‘blind sample’ is advantageous, in order to monitoring against a stated reference, in particular the inalterable SI being stable in time and space.
  • develop new methods of measurement.
  • estimate measurement uncertainty.

How to apply for a Grant Holder position at JRC-ITU?

All job vacancies (including Grantholders) are advertised on a central webpa

ge at the JRC, here you can browse institute specific roles and apply, you can also look specifically on the ESRA website which deals with the application process, it too lists the vacancies however they can be filtered by institute.

How to calculate the measurement uncertainty of PCR measurements?

In the

ts/guidance-document-measurement-uncertainty-gmo-testing-laboratories">Guidance Document on Measurement Uncertainty for GMO Testing Laboratories two selected approaches for the estimation of measurement uncertainty are proposed. The first approach presented in detail is using data from collaborative trial in combination with in-house quality control data. In case no suitable collaborative trial data are available, an alternative approach, using data obtained on within-laboratory samples, is presented.

Are the GMO CRMs of IRMM checked for the presence/absence of other GM events than the one certified?

The GMO CRMs are gravimetric mixtures of pure GM and non-GM powders certified for a specific GM event as mass fraction (g/kg). IRMM verifies the purity of the two raw materials used for production with respect to the presence of the particular GM event that is certified. The CRMs are not certified for the absence or adventitious presence of other (contaminating) GM events.

The GMO CRMs can be used as positive controls for the certified GM event for instance to validate a screening method. However, the GMO CRMs should not be used as negative controls for any other GM event than the one certified. Also the blank material of each series is certified to contain less than the certified amount for a given GM event and the absence of this event can not be guaranteed.

For additional information IRMM has conducted a study to verify the GM composition of 33 raw materials used for the production of the GMO CRMs. Those raw materials have been tested by quantitative PCR for the presence/absence of 39 single GM targets known for 7 plant species. It needs to be noted that adventitious presence of other GM events is likely to be heterogeneously distributed over the batch of raw material and needs to be taken into account when comparing the results obtained so far. These results are summarised in this document and provide an indication about possible adventitious presence.

How to collaborate with the JRC?

How to collaborate with the JRC if you are an organisation:

  • Pro
  • Institutional Networks – networks with partners contributing to the JRC's work programme;
  • Indirect Actions – JRC is allowed to participate in FP7 projects and networks under the same conditions as organisations from member states;
  • Collaboration Agreements – agreements which concern joint research, information sharing and sometimes the exchange of personnel.
  • Training courses and workshops – aiming at disseminating the results of individual projects and studies. To support Member States in implementation of EU policies (for workshops and trainings organised by the JRC institutes, visit theindividual institutes' home pages).
  • Information and awareness actions (Information Days & Round Tables, EU Presidency Events, Technical & high-level visits) – aiming at increasing awareness of the JRC activities to support EU policies and to promote collaboration between JRC and the Member States.
  • How to collaborate with the JRC if you are an individual:

    How to collaborate with the JRC in the framework of the JRC Enlargement & Integration Action:

    The JRC is playing an important role in providing scientific and technological support for EU enlargement and integration, through its Enlargement & Integration Action (E&IA). This action is specifically targeted at organisations and researchers from New Member States (EU2), Candidate and Potential Candidate Countries. Since 2005 the workshops and training possibilities are gradually opening for the partner countries of the European Neighbourhood Policy. In order to promote the co-operation with non EU countries associated to FP7 the JRC E&IA is now also open to Switzerland, Lichtenstein, Israel, Iceland and Norway.

    Similar instruments for collaborating with the JRC are available for the target countries in the framework of the E&IA:

    How to collaborate with the JRC if you are an organisation from an E&IA target country:

    • Projects – projects addressing specific needs of the Enlargement countries
    • Workshops – aiming to assist the competent organisations in the E&IA target countries with the scientific and technical methods and techniques underpinning EU policy implementation, learn about the methods currently available in the present or potential candidates of the EU and discuss future implementation
    • Information events – aiming at increasing awareness of the JRC activities to support EU policies and to promote collaboration between JRC and E&IA target countries. This is also a powerful instrument for generating interest among the major S&T institutions of a New ember States as well as raising awareness among the decision makers about the importance and relevance of the JRC for the country.

    How to collaborate with the JRC if you are an individual from an E&IA target country:

    • Temporary jobs – short/medium-term job openings which are available for experts from research organisations, national enforcement laboratories and scientists from the Enlargement & Integration Action target countries

    Is the ERM® concept a closed club?

    ERM® is not a closed club, but explicitly open to new members, who fulfi

    l the defined membership criteria as given at the ERM web site. The criteria are in brief:

    Be located within the European Union and be a signatory or designated laboratory of the CIPM-MRA.

    • Be a producer of certified reference materials who fulfils agreed quality standards,
    • in particular by having in place a quality system for the production of CRMs in accordance with ISO Guide 34 and 35.
    • Accept all principles of the ERM® Memorandum of Understanding.

    The three ‘founding’ partners of ERM® (BAM, IRMM, LGC) understand their role as being a nucleus.

    Is the ERM® concept only for EU producers?

    The trademark owner (European Community) is not prepared to give a licence f

    or the trademark to an institute outside the EU (in particular not for a trademark where the 'EU stars' are part of it).