We are doing science for policy
The Joint Research Centre (JRC) is the European Commission's science and knowledge service which employs scientists to carry out research in order to provide independent scientific advice and support to EU policy.
In a detailed analysis of the scientific literature, over 21,000 abstracts (11,636 non-cancer and 9,421 cancer) were scanned for relevant non-animal models of respiratory disease (e.g. asthma, COPD).
From this, a total of 284 publications were identified as the most representative and innovative models according to a set of inclusion/exclusion criteria. In vitro cell and tissue cultures, human ex vivo, in silico approaches were chiefly considered.
The result is a unique highly curated knowledge base containing detailed descriptions of non-animal models being used for respiratory disease research, including information on their applications and biological relevance.
It is freely available in an easy-to-use spreadsheet format from the EURL ECVAM Collection in the JRC Data Catalogue.
A technical report is also available with an analysis of the models and methods identified to describe the state-of-the-art from different perspectives, including the most prevalent model types, typical contexts of use and emerging trends.
A description of the review methodology used is also provided.
An executive summary has been produced for non-technical readers interested in how they can benefit from this study.
Download the leaflet: Advanced Non-animal Models in Biomedical Research: Respiratory Tract Diseases