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Skin Irritation: EpiSkin Skin Irritation Test (SIT)

The EpiSkin human epidermis model can be used to assess skin irritation potential of chemicals.

The method has previously been validated as part of the ECVAM international validation study on in vitro tests for acute skin irritation. Furthermore, the method has been peer-reviewed by ESAC and was recommended for consideration for regulatory approval for skin irritation assessments.

Subsequently, the test has been adopted as OECD test guideline (No 439).

The results of the validation study, the ESAC statement and our recommendation will be soon available on TSAR, the Tracking System for Alternative methods towards Regulatory acceptance.

Skin irritation

EpiSkin Skin Irritation Test (SIT)

Animal testing replacement

Validation study

Validation study outcomes

EURL ECVAM recommendations