EU Science Hub

Skin Irritation: EpiDerm Skin Irritation Test (SIT)

The EpiDerm Skin Irritation Test (SIT) method can be used to predict the skin irritation potential of chemicals/substances.

The method has previously been validated in a series of validation studies and has now received regulatory approval as a full replacement method for equivalent in vivo test methods for skin irritation potential.

The results of the validation study, the peer review of ESAC and our recommendation can be found on TSAR, the Tracking System for Alternative methods towards Regulatory acceptance.

Read more about the EpiDerm Skin Irritation Test (SIT) on TSAR

Skin irritation

EpiDerm Skin Irritation Test (SIT)

Animal testing replacement?

Validation studies

Validation study outcomes

EURL EVCAM recommendations