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Skin Corrosion: SkinEthic Skin Corrosion Test (SCT)

The SkinEthic Skin Corrosion Test (SCT) method can be used to predict the potential of chemicals to cause skin corrosion.

The test is based on measuring cytotoxic effects (via an MTT assay) following exposure to a chemical in the SkinEthic reconstructed human epidermis (SkinEthic RHE) model.

The approach has received regulatory approval as a replacement for in vivo skin corrosion tests (i.e. the in vivo Draize rabbit skin corrosion test). The test is also compliant with the OECD test guideline No 431.

The results of the validation study, the ESAC statement and our recommendation will be soon available on TSAR, the Tracking System for Alternative methods towards Regulatory acceptance.

Skin corrosion

SkinEthic Skin Corrosion Test (SCT)

Animal testing replacement

Validation study

Validation study outcome

EURL ECVAM recommendations