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Skin Corrosion: epiCS Skin Corrosion Test (SCT)

The epiCS (previously called EST-1000) Skin Corrosion Test (SCT) can be used to assess the potential of chemicals to cause skin corrosion.

The test involves the exposure of the epiCS model to test chemicals and subsequent determination of cytotoxicity via the MTT assay. The epiCS model is a reconstructed epidermis consisting of proliferating and differentiating keratinocytes.

The model underwent external validation and the EURL ECVAM Scientific Advisory Committee (ESAC) subsequently peer reviewed the data. A recommendation followed that the method can reliably predict the corrosive potential of chemicals.

The results of the validation study, the ESAC statement and our recommendation will be soon available on TSAR, the Tracking System for Alternative methods towards Regulatory acceptance.

Skin corrosion

epiCS Skin Corrosion Test (SCT)

Animal testing replacement

Validation study

Validation study outcomes

EURL ECVAM recommendations