EU Science Hub

EU-NETVAL (European Union Network of Laboratories for the Validation of Alternative Methods)

EU-NETVAL is a EURL ECVAM network of specialised laboratories located in the EU member states.

EU-NETVAL's mission is to provide support for EURL ECVAM validation studies to assess the reliability and relevance of alternative methods that have a potential to replace, reduce or refine the use of animals for scientific purposes.

EURL ECVAM coordinates EU-NETVAL and works closely with the Commission's Directorate-General for Environment to facilitate interaction with the National Contact Points for the implementation of Directive 2010/63/EU on the protection of animals used for scientific purposes.

EU-NETVAL was set up by EURL ECVAM in response to the provision of Directive 2010/63/EU on the protection of animals used for scientific purposes which requests that EU Member States assist the European Commission in the validation of alternative methods. Currently there are a total of 35 members of EU-NETVAL, selected against pre-defined eligibility criteria and endorsed by the National Contact Points.

The Terms of Reference for EU-NETVAL detail the legislative anchor, the establishment of the network and the maintenance of its membership, tasks of network members and of EURL ECVAM in support of validation studies, the allocation of tasks to members and the financing of the network activities.

The current network holds a range of expertise and competences and includes laboratories experienced in advanced in vitro procedures, test systems and measurement techniques which are considered important to address specific aims and objectives identified in EURL ECVAM's strategies to achieve Three Rs impact in different areas of regulatory safety testing.

Activities of EU-NETVAL

  1. Validation of the Transcriptional activation assay for detection of androgenic activity of chemicals (AR-CALUX) in vitro method
  1. Guidance Document on Good In Vitro Method Practices (GIVIMP)
  1. Validation of thyroid hormone disruption methods
  1. EU-NETVAL survey on miniaturised Ames tests
  1. Annual EU-NETVAL meeting