At the first meeting of the International Cooperation on Cosmetics Regulation (ICCR), an international group of cosmetics regulatory authorities consisting of the European Commission’s Directorate General for Internal Market, Industry, Entrepreneurship and SMEs (DG GROW), the US Food and Drug Administration (FDA), the Ministry of Health Labour and Welfare of Japan (MHLW), Health Canada and, since 2014, the Brazilian Health Regulatory Agency (ANVISA), in September 2007, the ICCR recognised the importance of reducing, refining and replacing animals used in toxicity testing.
The group also recommended that collaboration and communication in the design, execution, and peer review of validation studies for scientific alternatives to animal testing be further strengthened.
In response to this, institutes dealing with validation in Europe (EURL ECVAM), the US (ICCVAM and NICEATM), Japan (JaCVAM) and Canada (Health Canada) developed a framework to ensure that a collaborative approach was adopted in future studies and validation work. Furthermore, it was noted that the framework should be supported by scientific experts from regulatory bodies.
On 29 April 2009, representative from the four agencies signed a memorandum of cooperation (MOC) that finally established ICATM.
An updated MOC including the Korean Center for the Validation of Alternative Methods (KoCVAM) to the ICATM agreement was signed 8 March 2011.