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ESAC - EURL ECVAM Scientific Advisory Committee

The EURL ECVAM Scientific Advisory Committee (ESAC) advises EURL ECVAM on scientific issues.

ESAC's main role is to conduct independent peer reviews of validation studies of alternative test methods, assessing their scientific validity for a given purpose.

ESAC reviews the appropriateness of study design and management, the quality of the results obtained and the plausibility of the conclusions drawn.

ESAC Statements and Opinions

ESAC peer reviews are formally initiated with a "EURL ECVAM Request for ESAC Advice", which provides the necessary background for the peer-review and establishes its objectives, timelines and the questions to be addressed. ESAC peer reviews are normally prepared by specialised ESAC Working Groups (EWGs) and the ESAC's advice to EURL ECVAM is formally provided as "EWG Reports" and "ESAC Opinions" at the end of the peer review.

ESAC may also issue Opinions on other scientific matters of relevance to the work and mission of EURL ECVAM but not directly related to a specific alternative method. Adopted ESAC Opinions are published on the JRC Publications Repository and on the EURL ECVAM website as individual documents following a specific JRC Technical Report template (including as annexes and where applicable, the adopted EURL ECVAM Request for ESAC Advice and the EWG Report).

You can find out more about ESAC Statements and Opinions on TSAR (EURL ECVAM Tracking System for Alternative methods towards Regulatory acceptance).

Composition of ESAC and Procedures

The ESAC consists of a minimum of 9 core members plus ad hoc members.

The core members are appointed as individual experts on the basis of their personal capacity and scientific excellence.

The ad hoc members are eligible experts selected to serve in ESAC Working Groups (EWGs) based on their expertise on the test method(s) and/or scientific question(s) under review. Each EWG must comprise at least one core member who shall chair the EWG. Otherwise, EWGs may be composed of any combination of core and ad hoc members.

More details are available in the Terms of Reference.

ESAC Call for Applications

Every three years, EURL ECVAM publishes an open "Call for Applications" to renew the core membership of ESAC, directed to scientists with a wide range of expertise that may submit their candidacy by forwarding a motivation letter and a CV.

The latest call for application was launched in December 2016 with application deadline on 31 January 2017, before midnight.

Current ESAC members

The list of current ESAC members and the adopted Terms of Reference and Rules of Procedure can be found on the Register of Commission Expert Groups.

ESAC meetings

ESAC meetings are held on an as-needed basis but typically, the ESAC holds biannual meetings at the JRC in Ispra.

ESAC Statements 1999-2009

A note on procedure

ESAC operates in agreement with published Rules of Procedure.