Table 9-3: Predicted non-sensitisers with no obvious structural alerts.

Substance (INCI) name CAS number Structural alerts
6-Acetyl-1,1,2,4,4,7-hexamethyltetraline 21145-77-7
Benzyl acetone 2550-26-7 Schiff base; the combination of reactivity and hydrophobicity may not be enough to confer sensitisation
2-tert.-Butylcyclohexyl acetate 88-41-5
4-tert.-Butylcyclohexyl acetate 32210-23-4
Cyclohexyl acetate 622-45-7
Diphenyl ether 101-84-8
Substance (INCI) name CAS number  Structural alerts
Ethyl 2-methylbutyrate 7452-79-1
Ethylene dodecanioate 54982-83-1
Ethylene brassylate 105-95-3
Eucalyptol  470-82-6
Hexyl acetate 142-92-7
Hibiscolide 6707-60-4
Hydroxycitronellol 107-74-4  However, dehydration followed by autoxidation could give sensitising impurities
Isoamyl acetate 123-92-2
Isobornyl acetate 125-12-2
Methoxytrimethylheptanol  41890-92-0
Methyl p-anisate 121-98-2
Methyl anthranilate 134-20-3
Methylbenzyl acetate 93-92-5
Methyl dihydrojasmonate 24851-98-7  Schiff base; the combination of reactivity and hydrophobicity may not be enough to confer sensitisation
Oxalide 1725-01-5
Pentadecalactone 106-02-5
Phenethyl acetate 103-45-7
Phenethyl alcohol 60-12-8
Phenoxyethyl isobutyrate 103-60-6
Phenylisohexanol  55066-48-3
Phenylpropanol  122-97-4
Tetrahydrolinalool 78-69-3
Tetrahydro-methyl-methylpropyl)-pyran-4-ol 63500-71-0
Trimethylhexyl acetate 58430-94-7
Trimethyl-propylcyclohexanepropanol (tmch) 70788-30-6
gamma-Undecalactone 104-67-6

Source: SCCS,  Opinion on Fragrance allergens in cosmetic products, pages 69-70