Table 8-1: Summary of local lymph node assay (LLNA) data on 66 fragrance substances, based on a
report submitted by the Research Institute for Fragrance Materials, Inc. (RIFM, 2009 (164)) and in
published reviews by Gerberick et al. 2005 (165) and Kern et al. 2010 (166), respectively. EC3 values
(% and M) are given. The order of substances is by decreasing sensitisation potency as assessed by
LLNA EC3 values (lowest EC3 value indicating highest potency).
| Substance |
CAS no. |
EC3 value |
Reference |
| % |
M |
Notes: * Material with low levels of oxidation according to (164)
n/a: Not applicable (mixture of compounds).
M: EC3 based on molar concentration
|
| Hexyl salicylate |
6259-76-3 |
0.18 |
0.008 |
(164, 166) |
| Cinnamal |
104-55-2 |
0.2 |
0.015 |
(164) |
| Methyl 2-octynoate |
111-12-6 |
<0.5 |
<0.032 |
(164, 166) |
| Isoeugenol |
97-54-1 |
0.54 |
0.033 |
(164) |
| Citral |
5392-40-5 |
1.2 |
0.079 |
(164) |
| 2-Hexylidene cyclopentanone |
17373-89-6 |
2.4 |
0.14 |
(164) |
| Methyl octine carbonate |
111-80-8 |
2.5 |
0.15 |
(164) |
| Peru balsam absolute |
8007-00-9 |
2.5 |
n/a |
(164) |
| trans-2-Hexenal |
6728-26-3 |
2.6 |
0.26 |
(164) |
| Benzyl Salicylate |
118-58-1 |
2.9 |
0.23 |
(164, 166) |
| Butylphenyl methylpropional (BMHCA) |
80-54-6 |
2.9 |
0.14 |
(164) |
| Phenylacetaldehyde |
122-78-1 |
3 |
0.25 |
(164, 165) |
| Allyl phenoxyacetate |
7493-74-5 |
3.1 |
0.16 |
(164) |
| Benzylideneacetone |
122-57-6 |
3.7 |
0.25 |
(165) |
| 3-Propylidenephthalide |
17369-59-4 |
3.7 |
0.21 |
(164, 165) |
| Evernia prunastri extract oak moss |
90028-68-5 |
3.9 |
n/a |
(164) |
| Balsam oil, Peru (Myroxylon pereirae Klotzsch) |
8007-00-9 |
4 |
n/a |
(164) |
| Farnesol |
4602-84-0 |
4.1 |
0.18 |
(164) |
| p-t-Butyl-dihydrocinnamaldehyde |
18127-01-0 |
4.3 |
0.23 |
(164) |
| α-Methyl cinnamic aldehyde |
101-39-3 |
4.5 |
0.31 |
(164, 165) |
| Substance |
CAS no. |
EC3 value |
Reference |
|
| Hexyl salicylate |
6259-76-3 |
0.18 |
0.008 |
(164, 166) |
| Cinnamal |
104-55-2 |
0.2 |
0.015 |
(164) |
| Methyl 2-octynoate |
111-12-6 |
<0.5 |
<0.032 |
(164, 166) |
| Isoeugenol |
97-54-1 |
0.54 |
0.033 |
(164) |
| Citral |
5392-40-5 |
1.2 |
0.079 |
(164) |
| 2-Hexylidene cyclopentanone |
17373-89-6 |
2.4 |
0.14 |
(164) |
| Methyl octine carbonate |
111-80-8 |
2.5 |
0.15 |
(164) |
| Peru balsam absolute |
8007-00-9 |
2.5 |
n/a |
(164) |
| trans-2-Hexenal |
6728-26-3 |
2.6 |
0.26 |
(164) |
| Benzyl Salicylate |
118-58-1 |
2.9 |
0.23 |
(164, 166) |
| Butylphenyl methylpropional (BMHCA) |
80-54-6 |
2.9 |
0.14 |
(164) |
| Phenylacetaldehyde |
122-78-1 |
3 |
0.25 |
(164, 165) |
| Allyl phenoxyacetate |
7493-74-5 |
3.1 |
0.16 |
(164) |
| Benzylideneacetone |
122-57-6 |
3.7 |
0.25 |
(165) |
| 3-Propylidenephthalide |
17369-59-4 |
3.7 |
0.21 |
(164, 165) |
| Evernia prunastri extract oak moss |
90028-68-5 |
3.9 |
n/a |
(164) |
| Balsam oil, Peru (Myroxylon pereirae Klotzsch) |
8007-00-9 |
4 |
n/a |
(164) |
| Farnesol |
4602-84-0 |
4.1 |
0.18 |
(164) |
| p-t-Butyl-dihydrocinnamaldehyde |
18127-01-0 |
4.3 |
0.23 |
(164) |
| α-Methyl cinnamic aldehyde |
101-39-3 |
4.5 |
0.31 |
(164, 165) |
| Citronellol |
106-22-9 |
43.5 |
2.78 |
(164, 166) |
| No EC3 value was established; higher concentrations should also have been tested |
| 6-Methyl-3,5-heptadien-2-one |
1604-28-0 |
>5 |
>0.40 |
(164) |
| Camellia sinensis leaf tea leaf absolute |
84650-60-2 |
>5 |
N/a |
(164) |
| Cinnamyl nitrile |
1885-38-7 |
>10 |
>0.77 |
(164) |
| Menthadiene-7-methyl formate |
68683-20-5 |
>10 |
>0.51 |
(164) |
| Evernia furfuracea extract tree moss absolute |
90028-67-4 |
>20 |
N/a |
(164) |
| Isocyclogeraniol |
68527-77-5 |
>25 |
>1.62 |
(164) |
| 1-Octen-3-yl acetate |
2442-10-6 |
>30 |
>1.76 |
(164) |
| Benzyl alcohol |
100-51-6 |
>50 |
>4.62 |
(164) |
| Coumarin |
91-64-5 |
>50 |
>3.42 |
(164) |
| Vanillin |
121-33-5 |
>50 |
>3.3 |
(164) |
| No EC3 value calculated |
|
|
|
| Benzaldehyde |
100-52-7 |
- |
|
(165) |
Source:
SCCS,  Opinion on Fragrance allergens in cosmetic products, pages 59-61
|