Table 7-3: Fragrance substances with negative human data, i.e. patch tests of patients with suspected contact allergy to fragrance ingredients which yielded negative results.
INCI name (or, if none exists, perfuming name according to CosIng) CAS number Results / Comment Ref.
6-ACETYL-1,1,2,4,4,7-HEXAMETHYLTETRALINE 21145-77-7 0 / 313 consecutive patients in 2 centres (70)
AMYLCYCLOPENTANONE 4819-67-4 0 / 178 (171)
BENZYL ACETATE 140-11-4 0 / 100 consecutive patients in 1 centre observed (70)
2-TERT-BUTYLCYCLOHEXYL ACETATE 88-41-5 0 / 313 consecutive patients in 2 centres (70)
4-tert.-Butylcyclohexyl acetate 32210-23-4 0 / 107 consecutive patients in 1 centre observed (70)
6-ETHYLIDENEOCTAHYDRO-5,8-METHANO-2H-BENZO-1-PYRAN 93939-86-7 0 / 178 (171)
3α,4,5,6,7,7α-HEXAHYDRO-4,7-METHANO-1H-INDEN-5(OR 6)-YL ACETATE 54830-99-8 0 / 313 consecutive patients in 2 centres (70)
HEXYL SALICYLATE 6259-76-3 0 / 218 “top 100” substance and classified as R43 (173)
HIBISCOLIDE 6707-60-4 0 / 178 (171)
alpha-IONONE 127-41-3 0 / 205 (70)
beta-IONONE 79-77-6 0 / 205 “top 100” substance (70)
ISOBORNYL ACETATE 125-12-2 0 / 107 “top 100” substance (70)
METHYL ANTHRANILATE 134-20-3 0 / 91 “top 100” substance (188)
METHYL IONONE (mixture of isomers) 1335-46-2 0 / 100 “top 100” substance (70)
OXALIDE 1725-01-5 0 / 178 (171)
TERPINEOL ACETATE (Isomer mixture) 8007-35-0 0 / 106 “top 100” substance (70)
alpha-TERPINYL ACETATE 80-26-2 0 / 179 (139)
TRIMETHYL-PROPYLCYCLOHEXANEPROPANOL 70788-30-6 0 / 178 (171)

Source: SCCS,  Opinion on Fragrance allergens in cosmetic products, page 51