Table 7-2: Fragrance substances with positive human data, which are, however, not sufficient to categorise as “established contact allergen in humans”. More detailed information forming the basis of this evaluation can be found in Annex I of this opinion.

INCI name (or, if none exists, perfuming name according to CosIng) CAS number Comment Ref.
For a number of substances negative patch tests results were obtained, usually in rather small patient samples (max. 313 patients). For some of these substances exposure is substantial, according to data submitted from IFRA. It should be noted that a negative result does not rule out a notable sensitisation prevalence, as the study size has to be larger than, e.g. n=298 to yield a 95% CI which excludes a prevalence of 1% and larger than n=597 to exclude a prevalence of 0.5%.
AMBRETTOLIDE 7779-50-2 3.4% positive reactions in 178 patients (171)
CARVACROL 499-75-2 2 of 28 patients (Meynadier, after (172))
CUMINALDEHYDE 122-03-2 3 of 179 patients positive (139)
CYCLOHEXYL ACETATE 622-45-7 0.5% positive of 218 selected patients (173)
CYCLOPENTADECANONE 502-72-7 3 of 178 patients positive (171)
trans-trans-delta-DAMASCONE 71048-82-3 1 positive HRIPT (2/15 with 1%) (174)
2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE 116-26-7 1 positive HRIPT (5 of 53) (175).
DIMETHYLTETRAHYDRO BENZALDEHYDE 68737-61-1 2.3% positive reactions isomer mixture in 178 patients (171)
ETHYLENE DODECANEDIOATE 54982-83-1 2 / 218 positive PT reactions (173)
ETHYL VANILLIN 121-32-4 1 occupational case (176)
HELIOTROPINE 120-57-0 6 / 1606 consecutive patients positive (97)
HYDROXYCITRONELLOL 107-74-4 6.0% positive PT reactions in 218 patients (173)
ISOAMYL SALICYLATE 87-20-7 1 positive in 179 patients, possibly “excited back syndrome” 0 / 95 in another study with <= 1/10 of above test conc. (139) (70)
ISOLONGIFOLENEKETONE 33407-62-4 1 / 178 patients (171)
METHOXYCITRONELLAL 3613-30-7 Positive PT data of unknown validity by Nakayama et al. in 22/137 patients. (177)
METHOXYTRIMETHYLHEPTANOL 41890-92-0 0.9% positive PT (173)
METHYL p-ANISATE 121-98-2 1 / 182 patients positive (178)
METHYL CINNAMATE 103-26-4 6 / 142 patients positive (179)
METHYL DIHYDROJASMONATE 24851-98-7 3 / 1606 patients positive 0 / 100 (97) (70)
METHYLIONANTHEME 55599-63-8 1 case (180)
5-METHYL-alpha-IONONE 79-69-6 5 / 1606 (97)
METHYL OCTINE CARBONATE 111-80-8 1 case (181)
MYRCENE 123-35-3 1 / 1511 positive to oxidized myrcene (133)
MYRTENOL 515-00-4 2 HRIPTs with 1 pos. each (182)
NEROL 106-25-2 6.0% positive (173)
Nerolidol (isomer not specified) 7212-44-4 Few, unconfirmed pos. cases according to RIFM review (183)
NOPYL ACETATE 128-51-8 2 / 179 positive, possibly “excited back syndrome” (139)
PHENETHYL ALCOHOL 60-12-8 1 / 179; 0 / 100 (139) (70)
PHENYLACETALDEHYDE 122-78-1 1.1% of 182 positive. 1 case (178) (184)
PHENYLPROPANOL 122-97-4 2 / 218 (173)
PHYTOL 150-86-7 1 case in human max. test (185)
RHODINOL 6812-78-8 Several pos. HRIPTs, clinical data of uncertain validity (186)
trans-ROSE KETONE-5 39872-57-6 2 / 22 pos. HRIPT (187)

Source: SCCS,  Opinion on Fragrance allergens in cosmetic products, pages 49-50