Table 7-1: Established contact allergens in humans (summary of evaluation as detailed in chapter
6.3). More detailed information forming the basis of this evaluation can be found in Annex I of this
opinion.
| INCI name (or, if none exists, perfuming name according to CosIng) |
CAS number |
Comment: see text |
| Those substances which were categorised as +++ or more, i.e. those with the most
reported cases, were also the top ranking substances in large series of patients tested with
the 26 labelled fragrance ingredients ((44, 74) and additionally (170)). Geraniol is an
exeption, as it was all negative in the Danish study (170), but was still among the top ten in
the Dutch and German studies (44, 74), with prevalences of 0.5%-0.6% positives. Geraniol
has, in addition, caused many cases of contact allergy in other areas of Europe (49).
The use of absolute numbers allows the pooling of studies with different selection criteria.
Limonene and linalool were not tested in their oxidized forms in the three studies (44, 74,
170) and would not have been identified, if only these publications had been the basis of
assessment.
It should be noted that oxidised fragrence terpenes with defined content of the major
haptens formed after autoxidation have not been commercially available for testing in
dermatology clinics. In the published clinical studies testing oxidised fragrence terpenes, the
patch test preparations have been obtained specifically for the performed multicentre
studies. From 2012, patch test preparations of oxidised limonene and oxidised linalool with
defined content of the major allergens in the oxidation mixtures, i.e. the hydroperoxides,
are commercially available (see also chapter 5). |
| ACETYLCEDRENE |
32388-55-9 |
+ |
| AMYL CINNAMAL |
122-40-7 |
++ |
| AMYL CINNAMYL ALCOHOL |
101-85-9 |
++ |
| AMYL SALICYLATE |
2050-08-0 |
+ |
| trans-ANETHOLE |
4180-23-8 |
+ (r.t.) |
| ANISYL ALCOHOL |
105-13-5 |
+ |
| BENZALDEHYDE |
100-52-7 |
+ |
| BENZYL ALCOHOL |
100-51-6 |
++ |
| BENZYL BENZOATE |
120-51-4 |
++ |
| BENZYL CINNAMATE |
103-41-3 |
++ |
| BENZYL SALICYLATE |
118-58-1 |
++ |
| BUTYLPHENYL METHYLPROPIONAL (Lilial®) |
80-54-6 |
++ |
| CAMPHOR |
76-22-2 / 464-49-3 |
+ (r.t.) |
| beta-CARYOPHYLLENE (ox.) |
87-44-5 |
Non-ox.: +, ox.: + |
| CARVONE |
99-49-0 / 6485-40-1 / 2244-16-8 |
+ (r.t.) |
| CINNAMAL |
104-55-2 |
+++ |
| CINNAMYL ALCOHOL |
104-54-1 |
+++ |
| CITRAL |
5392-40-5 |
+++ |
| CITRONELLOL |
106-22-9 / 1117-61-9 / 7540-51-4 |
++ |
| COUMARIN |
91-64-5 |
+++ |
| (DAMASCENONE ) |
23696-85-7 |
+ (r.t.) |
| ROSE KETONE-4 |
|
|
| alpha-DAMASCONE (TMCHB)# |
43052-87-5 / 23726-94-5 |
++ |
| cis-beta-DAMASCONE # |
23726-92-3 |
+ |
| delta-DAMASCONE # |
57378-68-4 |
+ |
| DIMETHYLBENZYL CARBINYL ACETATE (DMBCA) |
151-05-3 |
+ |
| EUGENOL |
97-53-0 |
+++ |
| FARNESOL |
4602-84-0 |
+++ |
| GERANIOL |
106-24-1 |
+++ |
| HEXADECANOLACTONE |
109-29-5 |
+ (r.t.) |
| HEXAMETHYLINDANOPYRAN |
1222-05-5 |
++ |
| HEXYL CINNAMAL |
101-86-0 |
++ |
| HYDROXYISOHEXYL 3-CYCLOHEXENE CARBOXALDEHYDE (HICC) |
31906-04-4 / 51414-25-6 |
++++ |
| HYDROXYCITRONELLAL |
107-75-5 |
+++ |
| ISOEUGENOL |
97-54-1 |
+++ |
| alpha-ISOMETHYL IONONE |
127-51-5 |
++ |
| (DL)-LIMONENE |
138-86-3 |
++ (non-ox.); +++ (ox.) |
| LINALOOL |
78-70-6 |
++ (non-ox.) +++ (ox.) |
| LINALYL ACETATE |
115-95-7 |
+ |
| MENTHOL |
1490-04-6 / 89-78-1 / 2216-51-5 |
++ |
| 6-METHYL COUMARIN# |
92-48-8 |
++ (photo-allergy) |
| METHYL 2-OCTYNOATE |
111-12-6 |
++ |
| METHYL SALICYLATE |
119-36-8 |
+ |
| 3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL |
67801-20-1 |
++ (r.t.) |
| alpha-PINENE and beta-PINENE |
80-56-8 and 127-91-3, resp. |
++ |
| PROPYLIDENE PHTHALIDE |
17369-59-4 |
+ (r.t.) |
| SALICYLALDEHYDE |
90-02-8 |
++ |
| alpha-SANTALOL and beta-SANTALOL |
115-71-9 and 77- 42-9, resp. |
++ |
| SCLAREOL |
515-03-7 |
+ |
| TERPINEOL (mixture of isomers) |
8000-41-7 |
+ |
| alpha-TERPINEOL |
10482-56-1 / 98-55-5 |
| Terpinolene |
586-62-9 |
++ |
| TETRAMETHYL ACETYLOCTAHYDRONAPHTHALENES |
54464-57-2 /
54464-59-4 /
68155-66-8 /
68155-67-9 |
+ |
| TRIMETHYL-BENZENEPROPANOL (Majantol) |
103694-68-4 |
++ |
| VANILLIN |
121-33-5 |
++ |
Source:
SCCS,  Opinion on Fragrance allergens in cosmetic products, pages 46-48
|